2hgf: Difference between revisions

<StructureSection load='2hgf' size='340' side='right'caption='[[2hgf]]' scene=''>

<table><tr><td colspan='2'>[[2hgf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HGF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HGF FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 1 model</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hgf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hgf OCA], [https://pdbe.org/2hgf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hgf RCSB], [https://www.ebi.ac.uk/pdbsum/2hgf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hgf ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/HGF_HUMAN HGF_HUMAN] Defects in HGF are the cause of deafness autosomal recessive type 39 (DFNB39) [MIM:[https://omim.org/entry/608265 608265]. A form of profound prelingual sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.<ref>PMID:19576567</ref>  

[https://www.uniprot.org/uniprot/HGF_HUMAN HGF_HUMAN] Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization.<ref>PMID:15167892</ref> <ref>PMID:20624990</ref>  

     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hg/2hgf_consurf.spt"</scriptWhenChecked>

     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Bottaro DP]]

[[Category: Byrd RA]]

[[Category: Kaufman JD]]

[[Category: Mazzulla MJ]]

[[Category: Rubin JS]]

[[Category: Stahl SJ]]

[[Category: Wingfield PT]]

[[Category: Zhou H]]