2fvz: Difference between revisions

← Older edit

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:2fvz.gif|left|200px]]
- {{Structure
+==Human Inositol Monophosphosphatase 2==
-|PDB= 2fvz |SIZE=350|CAPTION= <scene name='initialview01'>2fvz</scene>, resolution 2.400&Aring;
+<StructureSection load='2fvz' size='340' side='right'caption='[[2fvz]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
-|SITE=
+== Structural highlights ==
-|LIGAND=
+<table><tr><td colspan='2'>[[2fvz]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FVZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FVZ FirstGlance]. <br>
-|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Inositol-phosphate_phosphatase Inositol-phosphate phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.25 3.1.3.25] </span>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
-|GENE= IMPA2, IMP.18P ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fvz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fvz OCA], [https://pdbe.org/2fvz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fvz RCSB], [https://www.ebi.ac.uk/pdbsum/2fvz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fvz ProSAT]</span></td></tr>
-|DOMAIN=
+</table>
-|RELATEDENTRY=
+== Function ==
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fvz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fvz OCA], [http://www.ebi.ac.uk/pdbsum/2fvz PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2fvz RCSB]</span>
+[https://www.uniprot.org/uniprot/IMPA2_HUMAN IMPA2_HUMAN] Can use myo-inositol monophosphates, scylloinositol 1,4-diphosphate, glucose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. Has been implicated as the pharmacological target for lithium Li(+) action in brain.<ref>PMID:17068342</ref>
-}}
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fv/2fvz_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2fvz ConSurf].
+<div style="clear:both"></div>
-'''Human Inositol Monophosphosphatase 2'''
+==See Also==
+*[[Inositol monophosphatase 3D structures|Inositol monophosphatase 3D structures]]
+== References ==
-==About this Structure==
+<references/>
-FVZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FVZ OCA].
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Inositol-phosphate phosphatase]]
+[[Category: Large Structures]]
-[[Category: Single protein]]
+[[Category: Arrowsmith C]]
-[[Category: Arrowsmith, C.]]
+[[Category: Berglund H]]
-[[Category: Berg, S Van Den.]]
+[[Category: Collins R]]
-[[Category: Berglund, H.]]
+[[Category: Edwards A]]
-[[Category: Collins, R.]]
+[[Category: Ehn M]]
-[[Category: Edwards, A.]]
+[[Category: Flodin S]]
-[[Category: Ehn, M.]]
+[[Category: Graslund S]]
-[[Category: Flodin, S.]]
+[[Category: Hallberg BM]]
-[[Category: Graslund, S.]]
+[[Category: Hammarstrom M]]
-[[Category: Hallberg, B M.]]
+[[Category: Hogbom M]]
-[[Category: Hammarstrom, M.]]
+[[Category: Holmberg-Schiavone L]]
-[[Category: Hogbom, M.]]
+[[Category: Kotenyova T]]
-[[Category: Holmberg-Schiavone, L.]]
+[[Category: Kursula P]]
-[[Category: Kotenyova, T.]]
+[[Category: Nilsson-Ehle P]]
-[[Category: Kursula, P.]]
+[[Category: Nordlund P]]
-[[Category: Nilsson-Ehle, P.]]
+[[Category: Nyman T]]
-[[Category: Nordlund, P.]]
+[[Category: Ogg D]]
-[[Category: Nyman, T.]]
+[[Category: Persson C]]
-[[Category: Ogg, D.]]
+[[Category: Sagemark J]]
-[[Category: Persson, C.]]
+[[Category: Stenmark P]]
-[[Category: SGC, Structural Genomics Consortium.]]
+[[Category: Sundstrom M]]
-[[Category: Sagemark, J.]]
+[[Category: Thorsell AG]]
-[[Category: Stenmark, P.]]
+[[Category: Van Den Berg S]]
-[[Category: Sundstrom, M.]]
+[[Category: Weigelt J]]
-[[Category: Thorsell, A G.]]
-[[Category: Weigelt, J.]]
-[[Category: inositol metabolism]]
-[[Category: inositol monophosphatase]]
-[[Category: sgc]]
-[[Category: structural genomic]]
-[[Category: structural genomics consortium]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:08:25 2008''