2fvz: Difference between revisions

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-[[Image:2fvz.png|left|200px]]
-{{STRUCTURE_2fvz|  PDB=2fvz  |  SCENE=  }}
+==Human Inositol Monophosphosphatase 2==
+<StructureSection load='2fvz' size='340' side='right'caption='[[2fvz]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
-===Human Inositol Monophosphosphatase 2===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2fvz]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FVZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FVZ FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
-==About this Structure==
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fvz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fvz OCA], [https://pdbe.org/2fvz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fvz RCSB], [https://www.ebi.ac.uk/pdbsum/2fvz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fvz ProSAT]</span></td></tr>
-[[2fvz]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FVZ OCA].
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/IMPA2_HUMAN IMPA2_HUMAN] Can use myo-inositol monophosphates, scylloinositol 1,4-diphosphate, glucose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. Has been implicated as the pharmacological target for lithium Li(+) action in brain.<ref>PMID:17068342</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fv/2fvz_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2fvz ConSurf].
+<div style="clear:both"></div>
 ==See Also==
-*[[Inositol Monophosphatase|Inositol Monophosphatase]]
+*[[Inositol monophosphatase 3D structures|Inositol monophosphatase 3D structures]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Inositol-phosphate phosphatase]]
+[[Category: Large Structures]]
-[[Category: Arrowsmith, C.]]
+[[Category: Arrowsmith C]]
-[[Category: Berg, S Van Den.]]
+[[Category: Berglund H]]
-[[Category: Berglund, H.]]
+[[Category: Collins R]]
-[[Category: Collins, R.]]
+[[Category: Edwards A]]
-[[Category: Edwards, A.]]
+[[Category: Ehn M]]
-[[Category: Ehn, M.]]
+[[Category: Flodin S]]
-[[Category: Flodin, S.]]
+[[Category: Graslund S]]
-[[Category: Graslund, S.]]
+[[Category: Hallberg BM]]
-[[Category: Hallberg, B M.]]
+[[Category: Hammarstrom M]]
-[[Category: Hammarstrom, M.]]
+[[Category: Hogbom M]]
-[[Category: Hogbom, M.]]
+[[Category: Holmberg-Schiavone L]]
-[[Category: Holmberg-Schiavone, L.]]
+[[Category: Kotenyova T]]
-[[Category: Kotenyova, T.]]
+[[Category: Kursula P]]
-[[Category: Kursula, P.]]
+[[Category: Nilsson-Ehle P]]
-[[Category: Nilsson-Ehle, P.]]
+[[Category: Nordlund P]]
-[[Category: Nordlund, P.]]
+[[Category: Nyman T]]
-[[Category: Nyman, T.]]
+[[Category: Ogg D]]
-[[Category: Ogg, D.]]
+[[Category: Persson C]]
-[[Category: Persson, C.]]
+[[Category: Sagemark J]]
-[[Category: SGC, Structural Genomics Consortium.]]
+[[Category: Stenmark P]]
-[[Category: Sagemark, J.]]
+[[Category: Sundstrom M]]
-[[Category: Stenmark, P.]]
+[[Category: Thorsell AG]]
-[[Category: Sundstrom, M.]]
+[[Category: Van Den Berg S]]
-[[Category: Thorsell, A G.]]
+[[Category: Weigelt J]]
-[[Category: Weigelt, J.]]
-[[Category: Hydrolase]]
-[[Category: Inositol metabolism]]
-[[Category: Inositol monophosphatase]]
-[[Category: Sgc]]
-[[Category: Structural genomic]]
-[[Category: Structural genomics consortium]]