2c60: Difference between revisions

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-[[Image:2c60.gif|left|200px]]<br /><applet load="2c60" size="350" color="white" frame="true" align="right" spinBox="true"
-caption="2c60, resolution 1.25&Aring;" />
-'''CRYSTAL STRUCTURE OF HUMAN MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 3 ISOFORM 2 PHOX DOMAIN AT 1.25 A RESOLUTION'''<br />
-==About this Structure==
+==crystal structure of human mitogen-activated protein kinase kinase kinase 3 isoform 2 phox domain at 1.25 A resolution==
-C60 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=CA:'>CA</scene> and <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C60 OCA].
+<StructureSection load='2c60' size='340' side='right'caption='[[2c60]], [[Resolution|resolution]] 1.25&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2c60]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C60 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2C60 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.25&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c60 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c60 OCA], [https://pdbe.org/2c60 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c60 RCSB], [https://www.ebi.ac.uk/pdbsum/2c60 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c60 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/M3K3_HUMAN M3K3_HUMAN] Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 and DDIT3 transcriptional regulators.<ref>PMID:9006902</ref> <ref>PMID:12912994</ref> <ref>PMID:14661019</ref> <ref>PMID:14743216</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c6/2c60_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2c60 ConSurf].
+<div style="clear:both"></div>
+==See Also==
+*[[Mitogen-activated protein kinase kinase kinase|Mitogen-activated protein kinase kinase kinase]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Non-specific serine/threonine protein kinase]]
+[[Category: Large Structures]]
-[[Category: Single protein]]
+[[Category: Arrowsmith C]]
-[[Category: Arrowsmith, C.]]
+[[Category: Burgess N]]
-[[Category: Burgess, N.]]
+[[Category: Debreczeni JE]]
-[[Category: Debreczeni, J E.]]
+[[Category: Edwards A]]
-[[Category: Delft, F Von.]]
+[[Category: Gileadi O]]
-[[Category: Edwards, A.]]
+[[Category: Knapp S]]
-[[Category: Gileadi, O.]]
+[[Category: Papagrigoriou E]]
-[[Category: Knapp, S.]]
+[[Category: Salah E]]
-[[Category: Papagrigoriou, E.]]
+[[Category: Sundstrom M]]
-[[Category: Salah, E.]]
+[[Category: Weigelt J]]
-[[Category: Sundstrom, M.]]
+[[Category: Von Delft F]]
-[[Category: Weigelt, J.]]
-[[Category: CA]]
-[[Category: GOL]]
-[[Category: atp-binding]]
-[[Category: kinase]]
-[[Category: magnesium]]
-[[Category: map/erk kinase kinase 3]]
-[[Category: map3k3]]
-[[Category: mapkkk3]]
-[[Category: mekk3]]
-[[Category: metal-binding]]
-[[Category: nucleotide-binding]]
-[[Category: phosphorylation]]
-[[Category: serine threonine phosphorylation]]
-[[Category: serine/threonine-protein kinase]]
-[[Category: transferase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:45:14 2008''