2c47: Difference between revisions

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-[[Image:2c47.png|left|200px]]
-{{STRUCTURE_2c47|  PDB=2c47  |  SCENE=  }}
+==Structure of casein kinase 1 gamma 2==
+<StructureSection load='2c47' size='340' side='right'caption='[[2c47]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
-===STRUCTURE OF CASEIN KINASE 1 GAMMA 2===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2c47]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C47 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2C47 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
-==About this Structure==
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5ID:(2R,3R,4S,5R)-2-(4-AMINO-5-IODO-7H-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-5-(HYDROXYMETHYL)TETRAHYDROFURAN-3,4-DIOL'>5ID</scene>, <scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-[[2c47]] is a 4 chain structure of [[Casein kinase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C47 OCA].
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c47 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c47 OCA], [https://pdbe.org/2c47 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c47 RCSB], [https://www.ebi.ac.uk/pdbsum/2c47 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c47 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/KC1G2_HUMAN KC1G2_HUMAN] Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling (By similarity). Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Hyperphosphorylation of the serine-repeat motif of COL4A3BP/CERT leads to its inactivation by dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis.<ref>PMID:15342122</ref> <ref>PMID:15077195</ref> <ref>PMID:18794808</ref> <ref>PMID:19005213</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c4/2c47_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2c47 ConSurf].
+<div style="clear:both"></div>
 ==See Also==
-*[[Casein kinase|Casein kinase]]
+*[[Casein kinase 3D structures|Casein kinase 3D structures]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Amos, A.]]
+[[Category: Large Structures]]
-[[Category: Arrowsmith, C.]]
+[[Category: Amos A]]
-[[Category: Ball, L.]]
+[[Category: Arrowsmith C]]
-[[Category: Bullock, A.]]
+[[Category: Ball L]]
-[[Category: Bunkoczi, G.]]
+[[Category: Bullock A]]
-[[Category: Das, S.]]
+[[Category: Bunkoczi G]]
-[[Category: Debreczeni, J.]]
+[[Category: Das S]]
-[[Category: Delft, F Von.]]
+[[Category: Debreczeni J]]
-[[Category: Edwards, A.]]
+[[Category: Edwards A]]
-[[Category: Eswaran, J.]]
+[[Category: Eswaran J]]
-[[Category: Fedorov, O.]]
+[[Category: Fedorov O]]
-[[Category: Knapp, S.]]
+[[Category: Knapp S]]
-[[Category: Rellos, P.]]
+[[Category: Rellos P]]
-[[Category: Sobott, F.]]
+[[Category: Sobott F]]
-[[Category: Sundstrom, M.]]
+[[Category: Sundstrom M]]
-[[Category: Turnbull, A.]]
+[[Category: Turnbull A]]
-[[Category: Ugochukwu, E.]]
+[[Category: Ugochukwu E]]
-[[Category: Weigelt, J.]]
+[[Category: Weigelt J]]
-[[Category: Actin cytoskeleton organisation]]
+[[Category: Von Delft F]]
-[[Category: Atp-binding]]
-[[Category: Serine/threonine kinase]]
-[[Category: Transferase]]
-[[Category: Wnt signaling pathway]]