2aaq: Difference between revisions

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-[[Image:2aaq.png|left|200px]]
-{{STRUCTURE_2aaq|  PDB=2aaq  |  SCENE=  }}
+==Crystal Structure Analysis of the human Glutahione Reductase, complexed with GoPI==
+<StructureSection load='2aaq' size='340' side='right'caption='[[2aaq]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
-===Crystal Structure Analysis of the human Glutahione Reductase, complexed with GoPI===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2aaq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AAQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AAQ FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
-==About this Structure==
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AU:GOLD+ION'>AU</scene>, <scene name='pdbligand=AUP:2-(2-PHENYL-3-PYRIDIN-2-YL-4,5,6,7-TETRAHYDRO-2H-ISOPHOSPHINDOL-1-YL)PYRIDINE'>AUP</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-[[2aaq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AAQ OCA].
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2aaq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aaq OCA], [https://pdbe.org/2aaq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2aaq RCSB], [https://www.ebi.ac.uk/pdbsum/2aaq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2aaq ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/GSHR_HUMAN GSHR_HUMAN] Maintains high levels of reduced glutathione in the cytosol.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/aa/2aaq_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2aaq ConSurf].
+<div style="clear:both"></div>
 ==See Also==
 *[[Glutathione Reductase|Glutathione Reductase]]
+__TOC__
-==Reference==
+</StructureSection>
-<ref group="xtra">PMID:016493712</ref><references group="xtra"/>
-[[Category: Glutathione-disulfide reductase]]
 [[Category: Homo sapiens]]
-[[Category: Becker, K.]]
+[[Category: Large Structures]]
-[[Category: Davioud-Charvet, E.]]
+[[Category: Becker K]]
-[[Category: Fritz-Wolf, K.]]
+[[Category: Davioud-Charvet E]]
-[[Category: Herold-Mende, C.]]
+[[Category: Fritz-Wolf K]]
-[[Category: Reau, R.]]
+[[Category: Herold-Mende C]]
-[[Category: Toth, K.]]
+[[Category: Reau R]]
-[[Category: Urig, S.]]
+[[Category: Toth K]]
-[[Category: Antioxidative system]]
+[[Category: Urig S]]
-[[Category: Disulfide reductase]]
-[[Category: Glutathione reduction]]
-[[Category: Gold-coordination]]
-[[Category: Homodimer]]
-[[Category: Oxidoreductase]]
-[[Category: Protein gold complex]]