1z68: Difference between revisions

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OCA

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 ==Crystal Structure Of Human Fibroblast Activation Protein alpha==
-<StructureSection load='1z68' size='340' side='right' caption='[[1z68]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
+<StructureSection load='1z68' size='340' side='right'caption='[[1z68]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1z68]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z68 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Z68 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1z68]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z68 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z68 FirstGlance]. <br>
-</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene><br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
-<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z68 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z68 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1z68 RCSB], [http://www.ebi.ac.uk/pdbsum/1z68 PDBsum]</span></td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-<table>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z68 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z68 OCA], [https://pdbe.org/1z68 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z68 RCSB], [https://www.ebi.ac.uk/pdbsum/1z68 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z68 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/SEPR_HUMAN SEPR_HUMAN] In association with DPP4 is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May have a role in tissue remodeling during development and wound healing, and may contribute to invasiveness in malignant cancers.<ref>PMID:16651416</ref>
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
 Check<jmol>
    <jmolCheckbox>
-     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z6/1z68_consurf.spt"</scriptWhenChecked>
+     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z6/1z68_consurf.spt"</scriptWhenChecked>
-     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
      <text>to colour the structure by Evolutionary Conservation</text>
    </jmolCheckbox>
-</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1z68 ConSurf].
 <div style="clear:both"></div>
 <div style="background-color:#fffaf0;">
@@ Line 24: / Line 28: @@
 From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 </div>
+<div class="pdbe-citations 1z68" style="background-color:#fffaf0;"></div>
 == References ==
 <references/>
@@ Line 29: / Line 34: @@
 </StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Aertgeerts, K.]]
+[[Category: Large Structures]]
-[[Category: Kraus, M L.]]
+[[Category: Aertgeerts K]]
-[[Category: Levin, I.]]
+[[Category: Kraus ML]]
-[[Category: Prasad, G S.]]
+[[Category: Levin I]]
-[[Category: Salakian, S.]]
+[[Category: Prasad GS]]
-[[Category: Shi, L.]]
+[[Category: Salakian S]]
-[[Category: Snell, G P.]]
+[[Category: Shi L]]
-[[Category: Sridhar, V.]]
+[[Category: Snell GP]]
-[[Category: Tennant, M G.]]
+[[Category: Sridhar V]]
-[[Category: Wijnands, R.]]
+[[Category: Tennant MG]]
-[[Category: Zhang, Y.]]
+[[Category: Wijnands R]]
-[[Category: Dipeptidylpeptidase]]
+[[Category: Zhang Y]]
-[[Category: Fapalpha]]
-[[Category: Fibroblast activation protein alpha]]
-[[Category: Integral membrane serine protease]]
-[[Category: Lyase]]
-[[Category: S9b]]
-[[Category: Seprase]]