1xmu: Difference between revisions
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==Catalytic Domain Of Human Phosphodiesterase 4B In Complex With Roflumilast== | ==Catalytic Domain Of Human Phosphodiesterase 4B In Complex With Roflumilast== | ||
<StructureSection load='1xmu' size='340' side='right' caption='[[1xmu]], [[Resolution|resolution]] 2.30Å' scene=''> | <StructureSection load='1xmu' size='340' side='right'caption='[[1xmu]], [[Resolution|resolution]] 2.30Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1xmu]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[1xmu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XMU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XMU FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ROF:3-(CYCLOPROPYLMETHOXY)-N-(3,5-DICHLOROPYRIDIN-4-YL)-4-(DIFLUOROMETHOXY)BENZAMIDE'>ROF</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xmu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xmu OCA], [https://pdbe.org/1xmu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xmu RCSB], [https://www.ebi.ac.uk/pdbsum/1xmu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xmu ProSAT]</span></td></tr> | |||
< | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xm/1xmu_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xm/1xmu_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/ | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xmu ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 1xmu" style="background-color:#fffaf0;"></div> | |||
==See Also== | ==See Also== | ||
*[[Phosphodiesterase|Phosphodiesterase]] | *[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Artis | [[Category: Large Structures]] | ||
[[Category: Bollag | [[Category: Artis DR]] | ||
[[Category: Card | [[Category: Bollag G]] | ||
[[Category: England | [[Category: Card GL]] | ||
[[Category: Fong | [[Category: England BP]] | ||
[[Category: Gillette | [[Category: Fong D]] | ||
[[Category: Ibrahim | [[Category: Gillette S]] | ||
[[Category: Kim | [[Category: Ibrahim PN]] | ||
[[Category: Lee | [[Category: Kim S-H]] | ||
[[Category: Luu | [[Category: Lee B]] | ||
[[Category: Milburn | [[Category: Luu C]] | ||
[[Category: Powell | [[Category: Milburn MV]] | ||
[[Category: Schlessinger | [[Category: Powell B]] | ||
[[Category: Suzuki | [[Category: Schlessinger J]] | ||
[[Category: Tabrizizad | [[Category: Suzuki Y]] | ||
[[Category: Zhang | [[Category: Tabrizizad M]] | ||
[[Category: Zhang KYJ]] | |||