1xm1: Difference between revisions

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-[[Image:1xm1.gif|left|200px]]
- {{Structure
+==Nonbasic Thrombin Inhibitor Complex==
-|PDB= 1xm1 |SIZE=350|CAPTION= <scene name='initialview01'>1xm1</scene>, resolution 2.30&Aring;
+<StructureSection load='1xm1' size='340' side='right'caption='[[1xm1]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
-|SITE=
+== Structural highlights ==
-|LIGAND= <scene name='pdbligand=GAH:N-{[(2S)-1-(N-{[4-({[AMINO(IMINO)METHYL]AMINO}METHYL)CYCLOHEXYL]CARBONYL}-3-CYCLOHEXYL-L-ALANYL)AZETIDIN-2-YL]CARBONYL}-L-TYROSYL-N~6~-[AMINO(IMINO)METHYL]-L-LYSINAMIDE'>GAH</scene>, <scene name='pdbligand=TYS:SULFONATED+TYROSINE'>TYS</scene>
+<table><tr><td colspan='2'>[[1xm1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Hirudo_medicinalis Hirudo medicinalis] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XM1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XM1 FirstGlance]. <br>
-|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Thrombin Thrombin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.5 3.4.21.5] </span>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
-|GENE=
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GAH:N-{[(2S)-1-(N-{[4-({[AMINO(IMINO)METHYL]AMINO}METHYL)CYCLOHEXYL]CARBONYL}-3-CYCLOHEXYL-L-ALANYL)AZETIDIN-2-YL]CARBONYL}-L-TYROSYL-N~6~-[AMINO(IMINO)METHYL]-L-LYSINAMIDE'>GAH</scene>, <scene name='pdbligand=TYS:O-SULFO-L-TYROSINE'>TYS</scene></td></tr>
-|DOMAIN=
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xm1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xm1 OCA], [https://pdbe.org/1xm1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xm1 RCSB], [https://www.ebi.ac.uk/pdbsum/1xm1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xm1 ProSAT]</span></td></tr>
-|RELATEDENTRY=[[1hgt|1HGT]]
+</table>
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xm1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xm1 OCA], [http://www.ebi.ac.uk/pdbsum/1xm1 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1xm1 RCSB]</span>
+== Function ==
-}}
+[https://www.uniprot.org/uniprot/HIRV1_HIRME HIRV1_HIRME] Hirudin is a potent thrombin-specific protease inhibitor. It forms a stable non-covalent complex with alpha-thrombin, thereby abolishing its ability to cleave fibrinogen.<ref>PMID:17585879</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xm/1xm1_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xm1 ConSurf].
+<div style="clear:both"></div>
-'''Nonbasic Thrombin Inhibitor Complex'''
+==See Also==
+*[[Hirudin 3D structures|Hirudin 3D structures]]
+*[[Thrombin 3D Structures|Thrombin 3D Structures]]
-==About this Structure==
+== References ==
-XM1 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XM1 OCA].
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Hirudo medicinalis]]
 [[Category: Homo sapiens]]
-[[Category: Single protein]]
+[[Category: Large Structures]]
-[[Category: Thrombin]]
+[[Category: Bode W]]
-[[Category: Bode, W.]]
+[[Category: Friedrich R]]
-[[Category: Friedrich, R.]]
+[[Category: Schwienhorst A]]
-[[Category: Schwienhorst, A.]]
-[[Category: inhibitor]]
-[[Category: nonbasic]]
-[[Category: thrombin]]
-[[Category: x-ray crystal structure]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:51:31 2008''