1xm1: Difference between revisions

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[[Image:1xm1.png|left|200px]]


{{STRUCTURE_1xm1|  PDB=1xm1  |  SCENE=  }}
==Nonbasic Thrombin Inhibitor Complex==
 
<StructureSection load='1xm1' size='340' side='right'caption='[[1xm1]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
===Nonbasic Thrombin Inhibitor Complex===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1xm1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Hirudo_medicinalis Hirudo medicinalis] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XM1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XM1 FirstGlance]. <br>
{{ABSTRACT_PUBMED_015528182}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GAH:N-{[(2S)-1-(N-{[4-({[AMINO(IMINO)METHYL]AMINO}METHYL)CYCLOHEXYL]CARBONYL}-3-CYCLOHEXYL-L-ALANYL)AZETIDIN-2-YL]CARBONYL}-L-TYROSYL-N~6~-[AMINO(IMINO)METHYL]-L-LYSINAMIDE'>GAH</scene>, <scene name='pdbligand=TYS:O-SULFO-L-TYROSINE'>TYS</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xm1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xm1 OCA], [https://pdbe.org/1xm1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xm1 RCSB], [https://www.ebi.ac.uk/pdbsum/1xm1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xm1 ProSAT]</span></td></tr>
[[1xm1]] is a 2 chain structure of [[Thrombin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XM1 OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/HIRV1_HIRME HIRV1_HIRME] Hirudin is a potent thrombin-specific protease inhibitor. It forms a stable non-covalent complex with alpha-thrombin, thereby abolishing its ability to cleave fibrinogen.<ref>PMID:17585879</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xm/1xm1_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xm1 ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Thrombin|Thrombin]]
*[[Hirudin 3D structures|Hirudin 3D structures]]
 
*[[Thrombin 3D Structures|Thrombin 3D Structures]]
==Reference==
== References ==
<ref group="xtra">PMID:015528182</ref><ref group="xtra">PMID:015937115</ref><references group="xtra"/>
<references/>
__TOC__
</StructureSection>
[[Category: Hirudo medicinalis]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Thrombin]]
[[Category: Large Structures]]
[[Category: Bode, W.]]
[[Category: Bode W]]
[[Category: Friedrich, R.]]
[[Category: Friedrich R]]
[[Category: Schwienhorst, A.]]
[[Category: Schwienhorst A]]
[[Category: Hydrolase]]
[[Category: Hydrolase-hydrolase inhibitor complex]]
[[Category: Inhibitor]]
[[Category: Nonbasic]]

Latest revision as of 10:38, 30 October 2024

Nonbasic Thrombin Inhibitor ComplexNonbasic Thrombin Inhibitor Complex

Structural highlights

1xm1 is a 2 chain structure with sequence from Hirudo medicinalis and Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.3Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

HIRV1_HIRME Hirudin is a potent thrombin-specific protease inhibitor. It forms a stable non-covalent complex with alpha-thrombin, thereby abolishing its ability to cleave fibrinogen.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Song X, Mo W, Liu X, Zhu L, Yan X, Song H, Dai L. The NMR solution structure of recombinant RGD-hirudin. Biochem Biophys Res Commun. 2007 Aug 17;360(1):103-8. Epub 2007 Jun 13. PMID:17585879 doi:10.1016/j.bbrc.2007.06.014

1xm1, resolution 2.30Å

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