1vdg: Difference between revisions

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-[[Image:1vdg.gif|left|200px]]
- {{Structure
+==Crystal structure of LIR1.01, one of the alleles of LIR1==
-|PDB= 1vdg |SIZE=350|CAPTION= <scene name='initialview01'>1vdg</scene>, resolution 2.80&Aring;
+<StructureSection load='1vdg' size='340' side='right'caption='[[1vdg]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
-|SITE=
+== Structural highlights ==
-|LIGAND=
+<table><tr><td colspan='2'>[[1vdg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VDG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1VDG FirstGlance]. <br>
-|ACTIVITY=
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
-|GENE=
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1vdg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vdg OCA], [https://pdbe.org/1vdg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1vdg RCSB], [https://www.ebi.ac.uk/pdbsum/1vdg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1vdg ProSAT]</span></td></tr>
-|DOMAIN=
+</table>
-|RELATEDENTRY=[[1g0x|1G0X]], [[1ufu|1UFU]], [[1ugn|1UGN]]
+== Function ==
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vdg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vdg OCA], [http://www.ebi.ac.uk/pdbsum/1vdg PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1vdg RCSB]</span>
+[https://www.uniprot.org/uniprot/LIRB1_HUMAN LIRB1_HUMAN] Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals and down-regulation of the immune response. Engagement of LILRB1 present on natural killer cells or T-cells by class I MHC molecules protects the target cells from lysis. Interaction with HLA-B or HLA-E leads to inhibition of the signal triggered by FCER1A and inhibits serotonin release. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.<ref>PMID:9285411</ref> <ref>PMID:9842885</ref> <ref>PMID:11907092</ref>
-}}
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vd/1vdg_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1vdg ConSurf].
+<div style="clear:both"></div>
-'''Crystal structure of LIR1.01, one of the alleles of LIR1'''
+==See Also==
+*[[Leukocyte immunoglobulin-like receptor|Leukocyte immunoglobulin-like receptor]]
+== References ==
-==About this Structure==
+<references/>
-VDG is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VDG OCA].
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Single protein]]
+[[Category: Large Structures]]
-[[Category: Amano, K.]]
+[[Category: Amano K]]
-[[Category: Kohda, D.]]
+[[Category: Kohda D]]
-[[Category: Kuroki, K.]]
+[[Category: Kuroki K]]
-[[Category: Maenaka, K.]]
+[[Category: Maenaka K]]
-[[Category: Rasubala, L.]]
+[[Category: Rasubala L]]
-[[Category: Shiroishi, M.]]
+[[Category: Shiroishi M]]
-[[Category: Tokunaga, K.]]
+[[Category: Tokunaga K]]
-[[Category: Tsuchiya, N.]]
+[[Category: Tsuchiya N]]
-[[Category: immunoglobulin-like]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:22:52 2008''