1sy6: Difference between revisions

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==Crystal Structure of CD3gammaepsilon Heterodimer in Complex with OKT3 Fab Fragment==
==Crystal Structure of CD3gammaepsilon Heterodimer in Complex with OKT3 Fab Fragment==
<StructureSection load='1sy6' size='340' side='right' caption='[[1sy6]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
<StructureSection load='1sy6' size='340' side='right'caption='[[1sy6]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1sy6]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SY6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1SY6 FirstGlance]. <br>
<table><tr><td colspan='2'>[[1sy6]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SY6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SY6 FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CD3G, T3G, CD3E, T3E ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1sy6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sy6 OCA], [http://pdbe.org/1sy6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1sy6 RCSB], [http://www.ebi.ac.uk/pdbsum/1sy6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1sy6 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1sy6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sy6 OCA], [https://pdbe.org/1sy6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1sy6 RCSB], [https://www.ebi.ac.uk/pdbsum/1sy6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1sy6 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/CD3G_HUMAN CD3G_HUMAN]] The CD3 complex mediates signal transduction.
[https://www.uniprot.org/uniprot/Q6PJA7_MOUSE Q6PJA7_MOUSE]  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sy/1sy6_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sy/1sy6_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
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*[[Antibody 3D structures|Antibody 3D structures]]
*[[Antibody 3D structures|Antibody 3D structures]]
*[[CD3|CD3]]
*[[CD3|CD3]]
*[[CD3 3D structures|CD3 3D structures]]
*[[Monoclonal Antibodies 3D structures|Monoclonal Antibodies 3D structures]]
*[[3D structures of non-human antibody|3D structures of non-human antibody]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Lk3 transgenic mice]]
[[Category: Large Structures]]
[[Category: Beddoe, T]]
[[Category: Mus musculus]]
[[Category: Brooks, A G]]
[[Category: Beddoe T]]
[[Category: Dunstone, M A]]
[[Category: Brooks AG]]
[[Category: Ely, L K]]
[[Category: Dunstone MA]]
[[Category: Kjer-Nielsen, L]]
[[Category: Ely LK]]
[[Category: Kostenko, L]]
[[Category: Kjer-Nielsen L]]
[[Category: McCluskey, J]]
[[Category: Kostenko L]]
[[Category: Misfud, N A]]
[[Category: McCluskey J]]
[[Category: Purcell, A W]]
[[Category: Misfud NA]]
[[Category: Rossjohn, J]]
[[Category: Purcell AW]]
[[Category: Cd3 epsilon]]
[[Category: Rossjohn J]]
[[Category: Cd3 gamma]]
[[Category: Okt3 fab]]
[[Category: Signaling protein-antibiotic complex]]

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