1rew: Difference between revisions

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OCA

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-[[Image:1rew.gif|left|200px]]<br />
-<applet load="1rew" size="450" color="white" frame="true" align="right" spinBox="true"
-caption="1rew, resolution 1.863&Aring;" />
-'''Structural refinement of the complex of bone morphogenetic protein 2 and its type IA receptor'''<br />
-==Overview==
+==Structural refinement of the complex of bone morphogenetic protein 2 and its type IA receptor==
-Bone morphogenetic protein-2 (BMP-2) and other members of the TGF-beta, superfamily regulate the development, maintenance and regeneration of, tissues and organs. Binding epitopes for these extracellular signaling, proteins have been defined, but hot spots specifying binding affinity and, specificity have so far not been identified. In this study, mutational and, structural analyses show that epitopes of BMP-2 and the BRIA receptor form, a new type of protein-protein interface. The main chain atoms of Leu 51, and Asp53 of BMP-2 represent a hot spot of binding to BRIA. The BMP-2, variant L51P was deficient in type I receptor binding only, whereas its, overall structure and its binding to type II receptors and modulator, proteins, such as noggin, were unchanged. Thus, the L51P substitution, converts BMP-2 into a receptor-inactive inhibitor of noggin. These results, are relevant for other proteins of the TGF-beta superfamily and provide, useful clues for structure-based drug design.
+<StructureSection load='1rew' size='340' side='right'caption='[[1rew]], [[Resolution|resolution]] 1.86&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1rew]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1REW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1REW FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.863&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1rew FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rew OCA], [https://pdbe.org/1rew PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1rew RCSB], [https://www.ebi.ac.uk/pdbsum/1rew PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1rew ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/BMP2_HUMAN BMP2_HUMAN] Induces cartilage and bone formation.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/re/1rew_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1rew ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Bone morphogenetic protein-2 (BMP-2) and other members of the TGF-beta superfamily regulate the development, maintenance and regeneration of tissues and organs. Binding epitopes for these extracellular signaling proteins have been defined, but hot spots specifying binding affinity and specificity have so far not been identified. In this study, mutational and structural analyses show that epitopes of BMP-2 and the BRIA receptor form a new type of protein-protein interface. The main chain atoms of Leu 51 and Asp53 of BMP-2 represent a hot spot of binding to BRIA. The BMP-2 variant L51P was deficient in type I receptor binding only, whereas its overall structure and its binding to type II receptors and modulator proteins, such as noggin, were unchanged. Thus, the L51P substitution converts BMP-2 into a receptor-inactive inhibitor of noggin. These results are relevant for other proteins of the TGF-beta superfamily and provide useful clues for structure-based drug design.
-==Disease==
+Molecular recognition of BMP-2 and BMP receptor IA.,Keller S, Nickel J, Zhang JL, Sebald W, Mueller TD Nat Struct Mol Biol. 2004 May;11(5):481-8. Epub 2004 Apr 4. PMID:15064755<ref>PMID:15064755</ref>
-Known diseases associated with this structure: Cowden-like syndrome OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=601299 601299]], Juvenile polyposis syndrome, infantile form OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=601299 601299]], Polyposis syndrome, hereditary mixed, 2 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=601299 601299]], Polyposis, juvenile intestinal OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=601299 601299]]
-==About this Structure==
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-REW is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Active as [http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1REW OCA].
+</div>
+<div class="pdbe-citations 1rew" style="background-color:#fffaf0;"></div>
-==Reference==
+==See Also==
-Molecular recognition of BMP-2 and BMP receptor IA., Keller S, Nickel J, Zhang JL, Sebald W, Mueller TD, Nat Struct Mol Biol. 2004 May;11(5):481-8. Epub 2004 Apr 4. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15064755 15064755]
+*[[Bone morphogenetic protein 3D structures|Bone morphogenetic protein 3D structures]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Non-specific serine/threonine protein kinase]]
+[[Category: Large Structures]]
-[[Category: Protein complex]]
+[[Category: Keller S]]
-[[Category: Keller, S.]]
+[[Category: Mueller TD]]
-[[Category: Mueller, T.D.]]
+[[Category: Nickel J]]
-[[Category: Nickel, J.]]
+[[Category: Sebald W]]
-[[Category: Sebald, W.]]
+[[Category: Zhang J-L]]
-[[Category: Zhang, J.L.]]
-[[Category: tgf-beta fold; bria-fold; 3-finger toxin fold]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 19:02:34 2007''