1osg: Difference between revisions

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OCA

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 ==Complex between BAFF and a BR3 derived peptide presented in a beta-hairpin scaffold==
-<StructureSection load='1osg' size='340' side='right' caption='[[1osg]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
+<StructureSection load='1osg' size='340' side='right'caption='[[1osg]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1osg]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OSG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OSG FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1osg]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OSG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OSG FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1mpv|1mpv]], [[1kxg|1kxg]]</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BAFF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1osg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1osg OCA], [https://pdbe.org/1osg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1osg RCSB], [https://www.ebi.ac.uk/pdbsum/1osg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1osg ProSAT]</span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1osg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1osg OCA], [http://pdbe.org/1osg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1osg RCSB], [http://www.ebi.ac.uk/pdbsum/1osg PDBsum]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/TN13B_HUMAN TN13B_HUMAN]] Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response.<ref>PMID:10973284</ref>   Isoform 2 seems to inhibit isoform 1 secretion and bioactivity (By similarity).<ref>PMID:10973284</ref>
+[https://www.uniprot.org/uniprot/TN13B_HUMAN TN13B_HUMAN] Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response.<ref>PMID:10973284</ref>   Isoform 2 seems to inhibit isoform 1 secretion and bioactivity (By similarity).<ref>PMID:10973284</ref>
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
 Check<jmol>
    <jmolCheckbox>
-     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/os/1osg_consurf.spt"</scriptWhenChecked>
+     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/os/1osg_consurf.spt"</scriptWhenChecked>
-     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
      <text>to colour the structure by Evolutionary Conservation</text>
    </jmolCheckbox>
@@ Line 29: / Line 29: @@
 </div>
 <div class="pdbe-citations 1osg" style="background-color:#fffaf0;"></div>
-==See Also==
-*[[Tumor necrosis factor receptor|Tumor necrosis factor receptor]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Human]]
+[[Category: Homo sapiens]]
-[[Category: Cochran, A G]]
+[[Category: Large Structures]]
-[[Category: Dixit, V M]]
+[[Category: Cochran AG]]
-[[Category: Fairbrother, W J]]
+[[Category: Dixit VM]]
-[[Category: Gordon, N C]]
+[[Category: Fairbrother WJ]]
-[[Category: Hymowitz, S G]]
+[[Category: Gordon NC]]
-[[Category: Kelley, R F]]
+[[Category: Hymowitz SG]]
-[[Category: Pan, B]]
+[[Category: Kelley RF]]
-[[Category: Starovasnik, M A]]
+[[Category: Pan B]]
-[[Category: Yan, M]]
+[[Category: Starovasnik MA]]
-[[Category: Yin, J P]]
+[[Category: Yan M]]
-[[Category: Beta hairpin]]
+[[Category: Yin JP]]
-[[Category: Immune system]]
-[[Category: Jelly-roll]]
-[[Category: Protein-peptide complex]]