1nfb: Difference between revisions

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-[[Image:1nfb.gif|left|200px]]
- {{Structure
+==Ternary complex of the human type II Inosine Monophosphate Dedhydrogenase with 6Cl-IMP and NAD==
-|PDB= 1nfb |SIZE=350|CAPTION= <scene name='initialview01'>1nfb</scene>, resolution 2.90&Aring;
+<StructureSection load='1nfb' size='340' side='right'caption='[[1nfb]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
-|SITE=
+== Structural highlights ==
-|LIGAND= <scene name='pdbligand=CPR:6-CHLOROPURINE+RIBOSIDE,+5'-MONOPHOSPHATE'>CPR</scene> and <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>
+<table><tr><td colspan='2'>[[1nfb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NFB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NFB FirstGlance]. <br>
-|ACTIVITY= [http://en.wikipedia.org/wiki/IMP_dehydrogenase IMP dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.205 1.1.1.205]
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
-|GENE= IMPDH2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CPR:6-CHLOROPURINE+RIBOSIDE,+5-MONOPHOSPHATE'>CPR</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
-}}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nfb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nfb OCA], [https://pdbe.org/1nfb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nfb RCSB], [https://www.ebi.ac.uk/pdbsum/1nfb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nfb ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/IMDH2_HUMAN IMDH2_HUMAN] Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.[HAMAP-Rule:MF_03156]
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nf/1nfb_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1nfb ConSurf].
+<div style="clear:both"></div>
-'''Ternary complex of the human type II Inosine Monophosphate Dedhydrogenase with 6Cl-IMP and NAD'''
+==See Also==
+*[[Inosine monophosphate dehydrogenase 3D structures|Inosine monophosphate dehydrogenase 3D structures]]
+__TOC__
-==About this Structure==
+</StructureSection>
-NFB is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NFB OCA].
 [[Category: Homo sapiens]]
-[[Category: IMP dehydrogenase]]
+[[Category: Large Structures]]
-[[Category: Single protein]]
+[[Category: Goldstein BM]]
-[[Category: Goldstein, B M.]]
+[[Category: Risal D]]
-[[Category: Risal, D.]]
+[[Category: Strickler MD]]
-[[Category: Strickler, M D.]]
-[[Category: CPR]]
-[[Category: NAD]]
-[[Category: 8 stranded paralle alpha/beta barrel]]
-[[Category: dehydrogenase]]
-[[Category: guanine nucleotide biosynthesis nad]]
-[[Category: impd]]
-[[Category: impdh]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:56:06 2008''