1n76: Difference between revisions

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-[[Image:1n76.png|left|200px]]
-{{STRUCTURE_1n76|  PDB=1n76  |  SCENE=  }}
+==CRYSTAL STRUCTURE OF HUMAN SEMINAL LACTOFERRIN AT 3.4 A RESOLUTION==
+<StructureSection load='1n76' size='340' side='right'caption='[[1n76]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
-===CRYSTAL STRUCTURE OF HUMAN SEMINAL LACTOFERRIN AT 3.4 A RESOLUTION===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1n76]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N76 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1N76 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.4&#8491;</td></tr>
-==About this Structure==
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-[[1n76]] is a 1 chain structure of [[Lactoferrin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N76 OCA].
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1n76 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n76 OCA], [https://pdbe.org/1n76 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1n76 RCSB], [https://www.ebi.ac.uk/pdbsum/1n76 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1n76 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/TRFL_HUMAN TRFL_HUMAN] Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate.<ref>PMID:12535064</ref> <ref>PMID:22320386</ref>   Lactotransferrin has antimicrobial activity which depends on the extracellular cation concentration.<ref>PMID:12535064</ref> <ref>PMID:22320386</ref>   Lactoferroxins A, B and C have opioid antagonist activity. Lactoferroxin A shows preference for mu-receptors, while lactoferroxin B and C have somewhat higher degrees of preference for kappa-receptors than for mu-receptors.<ref>PMID:12535064</ref> <ref>PMID:22320386</ref>   The lactotransferrin transferrin-like domain 1 functions as a serine protease of the peptidase S60 family that cuts arginine rich regions. This function contributes to the antimicrobial activity.<ref>PMID:12535064</ref> <ref>PMID:22320386</ref>   Isoform DeltaLf: transcription factor with antiproliferative properties and inducing cell cycle arrest. Binds to DeltaLf response element found in the SKP1, BAX, DCPS, and SELH promoters.<ref>PMID:12535064</ref> <ref>PMID:22320386</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/n7/1n76_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1n76 ConSurf].
+<div style="clear:both"></div>
 ==See Also==
 *[[Lactoferrin|Lactoferrin]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Betzel, Ch.]]
+[[Category: Large Structures]]
-[[Category: Bhushan, A.]]
+[[Category: Betzel C]]
-[[Category: Kaur, P.]]
+[[Category: Bhushan A]]
-[[Category: Kumar, J.]]
+[[Category: Kaur P]]
-[[Category: Munchau, S.]]
+[[Category: Kumar J]]
-[[Category: Paramsivam, M.]]
+[[Category: Munchau S]]
-[[Category: Sarvanan, K.]]
+[[Category: Paramsivam M]]
-[[Category: Sharma, S.]]
+[[Category: Sarvanan K]]
-[[Category: Singh, S B.]]
+[[Category: Sharma S]]
-[[Category: Singh, T P.]]
+[[Category: Singh SB]]
-[[Category: Srinivasan, A.]]
+[[Category: Singh TP]]
-[[Category: Weber, W.]]
+[[Category: Srinivasan A]]
-[[Category: Yadav, S.]]
+[[Category: Weber W]]
-[[Category: Antimicrobial protein]]
+[[Category: Yadav S]]
-[[Category: Human seminal lactoferrin]]