1kq6: Difference between revisions

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-{{STRUCTURE_1kq6|  PDB=1kq6  |  SCENE=  }}
-===p47phox PX domain===
-==Disease==
+==p47phox PX domain==
-[[http://www.uniprot.org/uniprot/NCF1_HUMAN NCF1_HUMAN]] Defects in NCF1 are the cause of chronic granulomatous disease autosomal recessive cytochrome-b-positive type 1 (CGD1) [MIM:[http://omim.org/entry/233700 233700]]. Chronic granulomatous disease is a genetically heterogeneous disorder characterized by the inability of neutrophils and phagocytes to kill microbes that they have ingested. Patients suffer from life-threatening bacterial/fungal infections.<ref>PMID:2011585</ref><ref>PMID:11133775</ref>
+<StructureSection load='1kq6' size='340' side='right'caption='[[1kq6]], [[Resolution|resolution]] 1.18&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1kq6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KQ6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KQ6 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.18&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kq6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kq6 OCA], [https://pdbe.org/1kq6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kq6 RCSB], [https://www.ebi.ac.uk/pdbsum/1kq6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kq6 ProSAT]</span></td></tr>
+</table>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kq/1kq6_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1kq6 ConSurf].
+<div style="clear:both"></div>
-==Function==
+==See Also==
-[[http://www.uniprot.org/uniprot/NCF1_HUMAN NCF1_HUMAN]] NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production).<ref>PMID:19801500</ref>
+*[[NADPH oxidase 3D structures|NADPH oxidase 3D structures]]
+__TOC__
-==About this Structure==
+</StructureSection>
-[[1kq6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KQ6 OCA].
-==Reference==
-<references group="xtra"/><references/>
 [[Category: Homo sapiens]]
-[[Category: Delbrueck, H.]]
+[[Category: Large Structures]]
-[[Category: Heinemann, U.]]
+[[Category: Delbrueck H]]
-[[Category: Oschkinat, H.]]
+[[Category: Heinemann U]]
-[[Category: Wahl, M.]]
+[[Category: Oschkinat H]]
-[[Category: Alpha beta]]
+[[Category: Wahl M]]
-[[Category: Nadph oxidase]]
-[[Category: Protein binding]]
-[[Category: Px domain]]