1ga3: Difference between revisions

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-{{Seed}}
-[[Image:1ga3.png|left|200px]]
-<!--
+==NMR STRUCTURE OF INTERLEUKIN-13==
-The line below this paragraph, containing "STRUCTURE_1ga3", creates the "Structure Box" on the page.
+<StructureSection load='1ga3' size='340' side='right'caption='[[1ga3]]' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1ga3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GA3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GA3 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ga3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ga3 OCA], [https://pdbe.org/1ga3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ga3 RCSB], [https://www.ebi.ac.uk/pdbsum/1ga3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ga3 ProSAT]</span></td></tr>
-{{STRUCTURE_1ga3|  PDB=1ga3  |  SCENE=  }}
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/IL13_HUMAN IL13_HUMAN] Defects in IL13 may be a cause of susceptibility to allergic rhinitis (ALRH) [MIM:[https://omim.org/entry/607154 607154]. Allergic rhinitis is a common disease of complex inheritance and is characterized by mucosal inflammation caused by allergen exposure.
+== Function ==
+[https://www.uniprot.org/uniprot/IL13_HUMAN IL13_HUMAN] Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ga/1ga3_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ga3 ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+The complex and interrelated function of the interleukin cytokines relies on a range of pro-inflammatory and anti-inflammatory immune responses mediated by an array of receptors, and there is considerable cross-reactivity for related cytokines. Recent findings continue to elucidate the expression patterns of interleukin receptors associated with a range of diseases, including cancer. We report here the first experimentally determined high-resolution structure of human interleukin-13 (IL-13). The experimental structure is significantly different from an earlier homology model, which could have led to improper estimation of receptor interaction surfaces and design of mutational experiments. Similarities between the presented IL-13 structure and the homologous interleukin-4 (IL-4) are discussed. Additionally, mutation data for IL-4 and IL-13 are analyzed and combined with a detailed structural analysis of the IL-4/IL4Ralpha interface that leads us to postulate interactions at the IL-13/receptor interface. The structural comparison is used to interpret the different affinities for various receptors and establishes the basis for further mutational experiments and antagonist design.
-===NMR STRUCTURE OF INTERLEUKIN-13===
+Solution structure of interleukin-13 and insights into receptor engagement.,Eisenmesser EZ, Horita DA, Altieri AS, Byrd RA J Mol Biol. 2001 Jun 29;310(1):231-41. PMID:11419949<ref>PMID:11419949</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 1ga3" style="background-color:#fffaf0;"></div>
-<!--
+==See Also==
-The line below this paragraph, {{ABSTRACT_PUBMED_11419949}}, adds the Publication Abstract to the page
+*[[Interleukin 3D structures|Interleukin 3D structures]]
-(as it appears on PubMed at http://www.pubmed.gov), where 11419949 is the PubMed ID number.
+== References ==
--->
+<references/>
-{{ABSTRACT_PUBMED_11419949}}
+__TOC__
+</StructureSection>
-==Disease==
-Known disease associated with this structure: Allergic rhinitis, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147683 147683]], Asthma, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147683 147683]]
-==About this Structure==
-GA3 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GA3 OCA].
-==Reference==
-Solution structure of interleukin-13 and insights into receptor engagement., Eisenmesser EZ, Horita DA, Altieri AS, Byrd RA, J Mol Biol. 2001 Jun 29;310(1):231-41. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11419949 11419949]
 [[Category: Homo sapiens]]
-[[Category: Single protein]]
+[[Category: Large Structures]]
-[[Category: Altieri, A S.]]
+[[Category: Altieri AS]]
-[[Category: Byrd, R A.]]
+[[Category: Byrd RA]]
-[[Category: Eisenmesser, E Z.]]
+[[Category: Eisenmesser EZ]]
-[[Category: Horita, D A.]]
+[[Category: Horita DA]]
-[[Category: Interleukin-13,il-13,il13,cytokine]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul  1 04:58:34 2008''