1fkc: Difference between revisions

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-{{Seed}}
-[[Image:1fkc.png|left|200px]]
-<!--
+==HUMAN PRION PROTEIN (MUTANT E200K) FRAGMENT 90-231==
-The line below this paragraph, containing "STRUCTURE_1fkc", creates the "Structure Box" on the page.
+<StructureSection load='1fkc' size='340' side='right'caption='[[1fkc]]' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1fkc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FKC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FKC FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 1 model</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fkc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fkc OCA], [https://pdbe.org/1fkc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fkc RCSB], [https://www.ebi.ac.uk/pdbsum/1fkc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fkc ProSAT]</span></td></tr>
-{{STRUCTURE_1fkc|  PDB=1fkc  |  SCENE=  }}
+</table>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fk/1fkc_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1fkc ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Prion propagation in transmissible spongiform encephalopathies involves the conversion of cellular prion protein, PrP(C), into a pathogenic conformer, PrP(Sc). Hereditary forms of the disease are linked to specific mutations in the gene coding for the prion protein. To gain insight into the molecular basis of these disorders, the solution structure of the familial Creutzfeldt-Jakob disease-related E200K variant of human prion protein was determined by multi-dimensional nuclear magnetic resonance spectroscopy. Remarkably, apart from minor differences in flexible regions, the backbone tertiary structure of the E200K variant is nearly identical to that reported for the wild-type human prion protein. The only major consequence of the mutation is the perturbation of surface electrostatic potential. The present structural data strongly suggest that protein surface defects leading to abnormalities in the interaction of prion protein with auxiliary proteins/chaperones or cellular membranes should be considered key determinants of a spontaneous PrP(C) --&gt; PrP(Sc) conversion in the E200K form of hereditary prion disease.
-===HUMAN PRION PROTEIN (MUTANT E200K) FRAGMENT 90-231===
+Solution structure of the E200K variant of human prion protein. Implications for the mechanism of pathogenesis in familial prion diseases.,Zhang Y, Swietnicki W, Zagorski MG, Surewicz WK, Sonnichsen FD J Biol Chem. 2000 Oct 27;275(43):33650-4. PMID:10954699<ref>PMID:10954699</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 1fkc" style="background-color:#fffaf0;"></div>
-<!--
+==See Also==
-The line below this paragraph, {{ABSTRACT_PUBMED_10954699}}, adds the Publication Abstract to the page
+*[[Prion 3D structures|Prion 3D structures]]
-(as it appears on PubMed at http://www.pubmed.gov), where 10954699 is the PubMed ID number.
+== References ==
--->
+<references/>
-{{ABSTRACT_PUBMED_10954699}}
+__TOC__
+</StructureSection>
-==About this Structure==
-FKC is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FKC OCA].
-==Reference==
-<ref group="xtra">PMID:10954699</ref><references group="xtra"/>
 [[Category: Homo sapiens]]
-[[Category: Soennichsen, F D.]]
+[[Category: Large Structures]]
-[[Category: Surewicz, W K.]]
+[[Category: Soennichsen FD]]
-[[Category: Swietnicki, W.]]
+[[Category: Surewicz WK]]
-[[Category: Zagorski, M G.]]
+[[Category: Swietnicki W]]
-[[Category: Zhang, Y.]]
+[[Category: Zagorski MG]]
-[[Category: Aggregation]]
+[[Category: Zhang Y]]
-[[Category: Creutzfeldt-jakob disease]]
-[[Category: Prion]]
-[[Category: Three helix]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 09:51:39 2009''