1d2q: Difference between revisions

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-{{Seed}}
-[[Image:1d2q.png|left|200px]]
-<!--
+==CRYSTAL STRUCTURE OF HUMAN TRAIL==
-The line below this paragraph, containing "STRUCTURE_1d2q", creates the "Structure Box" on the page.
+<StructureSection load='1d2q' size='340' side='right'caption='[[1d2q]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1d2q]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D2Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1D2Q FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1d2q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d2q OCA], [https://pdbe.org/1d2q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1d2q RCSB], [https://www.ebi.ac.uk/pdbsum/1d2q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1d2q ProSAT]</span></td></tr>
-{{STRUCTURE_1d2q|  PDB=1d2q  |  SCENE=  }}
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/TNF10_HUMAN TNF10_HUMAN] Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d2/1d2q_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1d2q ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+TRAIL is a newly identified cytokine belonging to the large tumor necrosis factor (TNF) family. TRAIL is a novel molecule inducing apoptosis in a wide variety of tumor cells but not in normal cells. To help in elucidating its biological roles and designing mutants with improved therapeutic potential, we have determined the crystal structure of human TRAIL. The structure reveals that a unique frame insertion of 12-16 amino acids adopts a salient loop structure penetrating into the receptor-binding site. The loop drastically alters the common receptor-binding surface of the TNF family most likely for the specific recognition of cognate partners. A structure-based mutagenesis study demonstrates a critical role of the insertion loop in the cytotoxic activity of TRAIL.
-===CRYSTAL STRUCTURE OF HUMAN TRAIL===
+.8 A resolution crystal structure of human TRAIL, a cytokine with selective antitumor activity.,Cha SS, Kim MS, Choi YH, Sung BJ, Shin NK, Shin HC, Sung YC, Oh BH Immunity. 1999 Aug;11(2):253-61. PMID:10485660<ref>PMID:10485660</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 1d2q" style="background-color:#fffaf0;"></div>
-<!--
+==See Also==
-The line below this paragraph, {{ABSTRACT_PUBMED_10485660}}, adds the Publication Abstract to the page
+*[[TRAIL|TRAIL]]
-(as it appears on PubMed at http://www.pubmed.gov), where 10485660 is the PubMed ID number.
+== References ==
--->
+<references/>
-{{ABSTRACT_PUBMED_10485660}}
+__TOC__
+</StructureSection>
-==About this Structure==
-D2Q is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D2Q OCA].
-==Reference==
-<ref group="xtra">PMID:10485660</ref><references group="xtra"/>
 [[Category: Homo sapiens]]
-[[Category: Cha, S S.]]
+[[Category: Large Structures]]
-[[Category: Cytokine]]
+[[Category: Cha S-S]]
-[[Category: Trail]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 09:52:30 2009''