1c5y: Difference between revisions

<StructureSection load='1c5y' size='340' side='right'caption='[[1c5y]], [[Resolution|resolution]] 1.65&Aring;' scene=''>

<table><tr><td colspan='2'>[[1c5y]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C5Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1C5Y FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65&#8491;</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ESP:THIENO[2,3-B]PYRIDINE-2-CARBOXAMIDINE'>ESP</scene>, <scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1c5y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c5y OCA], [https://pdbe.org/1c5y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1c5y RCSB], [https://www.ebi.ac.uk/pdbsum/1c5y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1c5y ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/UROK_HUMAN UROK_HUMAN] Defects in PLAU are the cause of Quebec platelet disorder (QPD) [MIM:[https://omim.org/entry/601709 601709]. QPD is an autosomal dominant bleeding disorder due to a gain-of-function defect in fibrinolysis. Although affected individuals do not exhibit systemic fibrinolysis, they show delayed onset bleeding after challenge, such as surgery. The hallmark of the disorder is markedly increased PLAU levels within platelets, which causes intraplatelet plasmin generation and secondary degradation of alpha-granule proteins.<ref>PMID:20007542</ref>  

[https://www.uniprot.org/uniprot/UROK_HUMAN UROK_HUMAN] Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.

     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c5/1c5y_consurf.spt"</scriptWhenChecked>

     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>

*[[Urokinase 3D Structures|Urokinase 3D Structures]]

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Chan H]]

[[Category: Katz BA]]

[[Category: Luong C]]

[[Category: Mackman R]]

[[Category: Martelli A]]

[[Category: Radika K]]

[[Category: Sprengeler PA]]

[[Category: Wang J]]

[[Category: Wong L]]