1bnd: Difference between revisions

<StructureSection load='1bnd' size='340' side='right'caption='[[1bnd]], [[Resolution|resolution]] 2.30&Aring;' scene=''>

<table><tr><td colspan='2'>[[1bnd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BND OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BND FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bnd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bnd OCA], [https://pdbe.org/1bnd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bnd RCSB], [https://www.ebi.ac.uk/pdbsum/1bnd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bnd ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/BDNF_HUMAN BDNF_HUMAN] Defects in BDNF are a cause of congenital central hypoventilation syndrome (CCHS) [MIM:[https://omim.org/entry/209880 209880]; also known as congenital failure of autonomic control or Ondine curse. CCHS is a rare disorder characterized by abnormal control of respiration in the absence of neuromuscular or lung disease, or an identifiable brain stem lesion. A deficiency in autonomic control of respiration results in inadequate or negligible ventilatory and arousal responses to hypercapnia and hypoxemia. CCHS is frequently complicated with neurocristopathies such as Hirschsprung disease that occurs in about 16% of CCHS cases.<ref>PMID:11840487</ref>  

[https://www.uniprot.org/uniprot/BDNF_HUMAN BDNF_HUMAN] During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability.<ref>PMID:12553913</ref>  

     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bn/1bnd_consurf.spt"</scriptWhenChecked>

     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Jones EY]]

[[Category: Radziejewski C]]

[[Category: Robinson RC]]

[[Category: Stuart DI]]