1a8m: Difference between revisions

<table><tr><td colspan='2'>[[1a8m]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A8M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1A8M FirstGlance]. <br>

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1a8m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a8m OCA], [https://pdbe.org/1a8m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1a8m RCSB], [https://www.ebi.ac.uk/pdbsum/1a8m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1a8m ProSAT]</span></td></tr>

[[https://www.uniprot.org/uniprot/TNFA_HUMAN TNFA_HUMAN]] Genetic variations in TNF are a cause of susceptibility psoriatic arthritis (PSORAS) [MIM:[https://omim.org/entry/607507 607507]]. PSORAS is an inflammatory, seronegative arthritis associated with psoriasis. It is a heterogeneous disorder ranging from a mild, non-destructive disease to a severe, progressive, erosive arthropathy. Five types of psoriatic arthritis have been defined: asymmetrical oligoarthritis characterized by primary involvement of the small joints of the fingers or toes; asymmetrical arthritis which involves the joints of the extremities; symmetrical polyarthritis characterized by a rheumatoidlike pattern that can involve hands, wrists, ankles, and feet; arthritis mutilans, which is a rare but deforming and destructive condition; arthritis of the sacroiliac joints and spine (psoriatic spondylitis).  

[[https://www.uniprot.org/uniprot/TNFA_HUMAN TNFA_HUMAN]] Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation.<ref>PMID:16829952</ref>  The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells.<ref>PMID:16829952</ref>

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*[[Tumor necrosis factor|Tumor necrosis factor]]

[[Category: Human]]

[[Category: Chen, M J]]

[[Category: Fu, Z Q]]

[[Category: Harrison, R W]]

[[Category: Reed, C]]

[[Category: Weber, I T]]

[[Category: Wu, J]]

[[Category: Xue, Y N]]

[[Category: Lymphokine]]