2hjl: Difference between revisions

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-{{Seed}}
-[[Image:2hjl.png|left|200px]]
-<!--
+==Crystal Structure of HLA-B5703 and HIV-1 peptide==
-The line below this paragraph, containing "STRUCTURE_2hjl", creates the "Structure Box" on the page.
+<StructureSection load='2hjl' size='340' side='right'caption='[[2hjl]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[2hjl]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HJL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HJL FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hjl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hjl OCA], [https://pdbe.org/2hjl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hjl RCSB], [https://www.ebi.ac.uk/pdbsum/2hjl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hjl ProSAT]</span></td></tr>
-{{STRUCTURE_2hjl|  PDB=2hjl  |  SCENE=  }}
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/Q1KW74_9HIV1 Q1KW74_9HIV1]
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hj/2hjl_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2hjl ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+HLA-B*57 is associated with slower disease progression to AIDS, and CD8+ T cell responses to B*57-restricted epitopes are thought to contribute to this protective effect. In this study, we evaluate the B*57-restricted p24 KAFSPEVIPMF (KF11) immune response which is immunodominant during chronic infection. Previously, we observed that the KF11 clade variants KGFNPEVIPMF [A2G,S4N] and KAFNPEIIMPF [S4N,V7I], sharing a position 4 mutation, are differentially recognized by KF11-specific T cells. By combining structural and cellular studies, we now demonstrate that the KF11 and [A2G,S4N] epitopes induce distinct functional responses in [A2G,S4N] and KF11-specific T cells, respectively, despite minimal structural differences between the individual B*57-peptide complexes. Recently, we also elucidated the highly distinct structure of KF11 in complex with B*5703, and have now characterized the CD8+ T cell repertoire recognizing this epitope. We now report striking features of TCR conservation both in terms of TCR Valpha and Vbeta chain usage, and throughout the hypervariable region. Collectively, our findings highlight unusual features of the B*5701/B*5703-KF11-specific immune responses which could influence disease progression and that might be important to consider when designing future vaccine regimens.
-===Crystal Structure of HLA-B5703 and HIV-1 peptide===
+Strong TCR conservation and altered T cell cross-reactivity characterize a B*57-restricted immune response in HIV-1 infection.,Gillespie GM, Stewart-Jones G, Rengasamy J, Beattie T, Bwayo JJ, Plummer FA, Kaul R, McMichael AJ, Easterbrook P, Dong T, Jones EY, Rowland-Jones SL J Immunol. 2006 Sep 15;177(6):3893-902. PMID:16951352<ref>PMID:16951352</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 2hjl" style="background-color:#fffaf0;"></div>
-<!--
+==See Also==
-The line below this paragraph, {{ABSTRACT_PUBMED_16951352}}, adds the Publication Abstract to the page
+*[[Beta-2 microglobulin 3D structures|Beta-2 microglobulin 3D structures]]
-(as it appears on PubMed at http://www.pubmed.gov), where 16951352 is the PubMed ID number.
+*[[MHC 3D structures|MHC 3D structures]]
--->
+*[[MHC I 3D structures|MHC I 3D structures]]
-{{ABSTRACT_PUBMED_16951352}}
+== References ==
+<references/>
-==About this Structure==
+__TOC__
-HJL is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HJL OCA].
+</StructureSection>
-==Reference==
-Strong TCR conservation and altered T cell cross-reactivity characterize a B*57-restricted immune response in HIV-1 infection., Gillespie GM, Stewart-Jones G, Rengasamy J, Beattie T, Bwayo JJ, Plummer FA, Kaul R, McMichael AJ, Easterbrook P, Dong T, Jones EY, Rowland-Jones SL, J Immunol. 2006 Sep 15;177(6):3893-902. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16951352 16951352]
 [[Category: Homo sapiens]]
-[[Category: Protein complex]]
+[[Category: Human immunodeficiency virus 1]]
-[[Category: Beattie, T.]]
+[[Category: Large Structures]]
-[[Category: Bwayo, J J.]]
+[[Category: Beattie T]]
-[[Category: Gillespie, G M.A.]]
+[[Category: Bwayo JJ]]
-[[Category: Plummer, F A.]]
+[[Category: Gillespie GMA]]
-[[Category: Rengasamy, J.]]
+[[Category: Plummer FA]]
-[[Category: Stewart-Jones, G.]]
+[[Category: Rengasamy J]]
-[[Category: B57]]
+[[Category: Stewart-Jones G]]
-[[Category: Hiv]]
-[[Category: Hla]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 14:01:05 2008''