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==Crystal structure of Human anti-HIV-1 GP120-reactive antibody E51==
==Crystal structure of Human anti-HIV-1 GP120-reactive antibody E51==
<StructureSection load='1rzf' size='340' side='right' caption='[[1rzf]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
<StructureSection load='1rzf' size='340' side='right'caption='[[1rzf]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1rzf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RZF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1RZF FirstGlance]. <br>
<table><tr><td colspan='2'>[[1rzf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RZF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RZF FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1rz7|1rz7]], [[1rz8|1rz8]], [[1rzg|1rzg]], [[1rzi|1rzi]], [[1rzj|1rzj]], [[1rzk|1rzk]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rzf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rzf OCA], [http://pdbe.org/1rzf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1rzf RCSB], [http://www.ebi.ac.uk/pdbsum/1rzf PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1rzf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rzf OCA], [https://pdbe.org/1rzf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1rzf RCSB], [https://www.ebi.ac.uk/pdbsum/1rzf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1rzf ProSAT]</span></td></tr>
</table>
</table>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
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Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rz/1rzf_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rz/1rzf_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1rzf ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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==See Also==
==See Also==
*[[Antibody|Antibody]]
*[[Antibody 3D structures|Antibody 3D structures]]
*[[Sandbox 20009|Sandbox 20009]]
*[[3D structures of human antibody|3D structures of human antibody]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Choe, H]]
[[Category: Large Structures]]
[[Category: Dimitrov, D S]]
[[Category: Choe H]]
[[Category: Farzan, M]]
[[Category: Dimitrov DS]]
[[Category: Hendrickson, W A]]
[[Category: Farzan M]]
[[Category: Huang, C C]]
[[Category: Hendrickson WA]]
[[Category: Kwong, P D]]
[[Category: Huang CC]]
[[Category: Majeed, S]]
[[Category: Kwong PD]]
[[Category: Moore, M J]]
[[Category: Majeed S]]
[[Category: Phogat, S]]
[[Category: Moore MJ]]
[[Category: Robinson, J]]
[[Category: Phogat S]]
[[Category: Sodroski, J]]
[[Category: Robinson J]]
[[Category: Venturi, M]]
[[Category: Sodroski J]]
[[Category: Wyatt, R]]
[[Category: Venturi M]]
[[Category: Zhang, M Y]]
[[Category: Wyatt R]]
[[Category: Antibody]]
[[Category: Zhang M-Y]]
[[Category: Cd4i]]
[[Category: Gp120]]
[[Category: Hiv-1]]
[[Category: Immune system]]
[[Category: Tyrosine sulfation]]
[[Category: Vh-gene usage]]

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