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[[Image:1rzf.gif|left|200px]]


{{Structure
==Crystal structure of Human anti-HIV-1 GP120-reactive antibody E51==
|PDB= 1rzf |SIZE=350|CAPTION= <scene name='initialview01'>1rzf</scene>, resolution 1.70&Aring;
<StructureSection load='1rzf' size='340' side='right'caption='[[1rzf]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene> and <scene name='pdbligand=IPA:ISOPROPYL ALCOHOL'>IPA</scene>
<table><tr><td colspan='2'>[[1rzf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RZF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RZF FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
|GENE=  
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene></td></tr>
}}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1rzf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rzf OCA], [https://pdbe.org/1rzf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1rzf RCSB], [https://www.ebi.ac.uk/pdbsum/1rzf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1rzf ProSAT]</span></td></tr>
</table>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rz/1rzf_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1rzf ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The conserved surface of the HIV-1 gp120 envelope glycoprotein that binds to the HIV-1 coreceptor is protected from humoral recognition by multiple layers of camouflage. Here we present sequence and genomic analyses for 12 antibodies that pierce these defenses and determine the crystal structures of 5. The data reveal mechanisms and atomic-level details for three unusual immune features: posttranslational mimicry of coreceptor by tyrosine sulfation of antibody, an alternative molecular mechanism controlling such sulfation, and highly selective V(H)-gene usage. When confronted by extraordinary viral defenses, the immune system unveils novel adaptive capabilities, with tyrosine sulfation enhancing the vocabulary of antigen recognition.


'''Crystal structure of Human anti-HIV-1 GP120-reactive antibody E51'''
Structural basis of tyrosine sulfation and VH-gene usage in antibodies that recognize the HIV type 1 coreceptor-binding site on gp120.,Huang CC, Venturi M, Majeed S, Moore MJ, Phogat S, Zhang MY, Dimitrov DS, Hendrickson WA, Robinson J, Sodroski J, Wyatt R, Choe H, Farzan M, Kwong PD Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):2706-11. Epub 2004 Feb 23. PMID:14981267<ref>PMID:14981267</ref>


From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 1rzf" style="background-color:#fffaf0;"></div>


==Overview==
==See Also==
The conserved surface of the HIV-1 gp120 envelope glycoprotein that binds to the HIV-1 coreceptor is protected from humoral recognition by multiple layers of camouflage. Here we present sequence and genomic analyses for 12 antibodies that pierce these defenses and determine the crystal structures of 5. The data reveal mechanisms and atomic-level details for three unusual immune features: posttranslational mimicry of coreceptor by tyrosine sulfation of antibody, an alternative molecular mechanism controlling such sulfation, and highly selective V(H)-gene usage. When confronted by extraordinary viral defenses, the immune system unveils novel adaptive capabilities, with tyrosine sulfation enhancing the vocabulary of antigen recognition.
*[[Antibody 3D structures|Antibody 3D structures]]
 
*[[Sandbox 20009|Sandbox 20009]]
==About this Structure==
*[[3D structures of human antibody|3D structures of human antibody]]
1RZF is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RZF OCA].
== References ==
 
<references/>
==Reference==
__TOC__
Structural basis of tyrosine sulfation and VH-gene usage in antibodies that recognize the HIV type 1 coreceptor-binding site on gp120., Huang CC, Venturi M, Majeed S, Moore MJ, Phogat S, Zhang MY, Dimitrov DS, Hendrickson WA, Robinson J, Sodroski J, Wyatt R, Choe H, Farzan M, Kwong PD, Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):2706-11. Epub 2004 Feb 23. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14981267 14981267]
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Protein complex]]
[[Category: Large Structures]]
[[Category: Choe, H.]]
[[Category: Choe H]]
[[Category: Dimitrov, D S.]]
[[Category: Dimitrov DS]]
[[Category: Farzan, M.]]
[[Category: Farzan M]]
[[Category: Hendrickson, W A.]]
[[Category: Hendrickson WA]]
[[Category: Huang, C C.]]
[[Category: Huang CC]]
[[Category: Kwong, P D.]]
[[Category: Kwong PD]]
[[Category: Majeed, S.]]
[[Category: Majeed S]]
[[Category: Moore, M J.]]
[[Category: Moore MJ]]
[[Category: Phogat, S.]]
[[Category: Phogat S]]
[[Category: Robinson, J.]]
[[Category: Robinson J]]
[[Category: Sodroski, J.]]
[[Category: Sodroski J]]
[[Category: Venturi, M.]]
[[Category: Venturi M]]
[[Category: Wyatt, R.]]
[[Category: Wyatt R]]
[[Category: Zhang, M Y.]]
[[Category: Zhang M-Y]]
[[Category: GOL]]
[[Category: IPA]]
[[Category: hiv-1; gp120; cd4i; antibodies; tyrosine sulfation; vh-gene usage]]
 
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