1hh6: Difference between revisions

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-{{Seed}}
-[[Image:1hh6.png|left|200px]]
-<!--
+==ANTI-P24 (HIV-1) FAB FRAGMENT CB41 COMPLEXED WITH A PEPTIDE==
-The line below this paragraph, containing "STRUCTURE_1hh6", creates the "Structure Box" on the page.
+<StructureSection load='1hh6' size='340' side='right'caption='[[1hh6]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1hh6]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HH6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HH6 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hh6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hh6 OCA], [https://pdbe.org/1hh6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hh6 RCSB], [https://www.ebi.ac.uk/pdbsum/1hh6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hh6 ProSAT]</span></td></tr>
-{{STRUCTURE_1hh6|  PDB=1hh6  |  SCENE=  }}
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/IGKC_MOUSE IGKC_MOUSE]
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hh/1hh6_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hh6 ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+We identified evolutionary pathways for the inter- conversion of three sequentially and structurally unrelated peptides, GATPEDLNQKL, GLYEWGGARI and FDKEWNLIEQN, binding to the same site of the hypervariable region of the anti-p24 (HIV-1) monoclonal antibody CB4-1. Conversion of these peptides into each other could be achieved in nine or 10 single amino acid substitution steps without loss of antibody binding. Such pathways were identified by analyzing all 7 620 480 pathways connecting 2560 different peptides, and testing them for CB4-1 binding. The binding modes of intermediate peptides of selected optimal pathways were characterized using complete sets of substitution analogs, revealing that a number of sequential substitutions accumulated without changing the pattern of key interacting residues. At a distinct step, however, one single amino acid exchange induces a sudden change in the binding mode, indicating a flip in specificity and conformation. Our data represent a model of how different specificities, structures and functions might evolve in protein-protein recognition.
-===ANTI-P24 (HIV-1) FAB FRAGMENT CB41 COMPLEXED WITH A PEPTIDE===
+Evolutionary transition pathways for changing peptide ligand specificity and structure.,Hoffmuller U, Knaute T, Hahn M, Hohne W, Schneider-Mergener J, Kramer A EMBO J. 2000 Sep 15;19(18):4866-74. PMID:10990450<ref>PMID:10990450</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-<!--
+</div>
-The line below this paragraph, {{ABSTRACT_PUBMED_10990450}}, adds the Publication Abstract to the page
+<div class="pdbe-citations 1hh6" style="background-color:#fffaf0;"></div>
-(as it appears on PubMed at http://www.pubmed.gov), where 10990450 is the PubMed ID number.
+== References ==
--->
+<references/>
-{{ABSTRACT_PUBMED_10990450}}
+__TOC__
+</StructureSection>
-==About this Structure==
+[[Category: Large Structures]]
-HH6 is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HH6 OCA].
-==Reference==
-<ref group="xtra">PMID:10990450</ref><ref group="xtra">PMID:9413990</ref><references group="xtra"/>
 [[Category: Mus musculus]]
-[[Category: Hahn, M.]]
+[[Category: Synthetic construct]]
-[[Category: Hohne, W.]]
+[[Category: Hahn M]]
-[[Category: Schneider-Mergener, J.]]
+[[Category: Hohne W]]
-[[Category: Wessner, H.]]
+[[Category: Schneider-Mergener J]]
-[[Category: Antibody/peptide]]
+[[Category: Wessner H]]
-[[Category: Crossreactivity]]
-[[Category: Fab-fragment]]
-[[Category: Hiv-1]]
-[[Category: Immune system]]
-[[Category: Peptide]]
-[[Category: Polyspecificity]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 17 09:05:19 2009''