1cfn: Difference between revisions

← Older edit

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:1cfn.gif|left|200px]]
-<!--
+==ANTI-P24 (HIV-1) FAB FRAGMENT CB41 COMPLEXED WITH AN EPITOPE-RELATED PEPTIDE==
-The line below this paragraph, containing "STRUCTURE_1cfn", creates the "Structure Box" on the page.
+<StructureSection load='1cfn' size='340' side='right'caption='[[1cfn]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1cfn]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CFN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CFN FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.65&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NLE:NORLEUCINE'>NLE</scene></td></tr>
-{{STRUCTURE_1cfn|  PDB=1cfn  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1cfn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cfn OCA], [https://pdbe.org/1cfn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1cfn RCSB], [https://www.ebi.ac.uk/pdbsum/1cfn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1cfn ProSAT]</span></td></tr>
+</table>
-'''ANTI-P24 (HIV-1) FAB FRAGMENT CB41 COMPLEXED WITH AN EPITOPE-RELATED PEPTIDE'''
+== Function ==
+[https://www.uniprot.org/uniprot/IGKC_MOUSE IGKC_MOUSE]
+== Evolutionary Conservation ==
-==Overview==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cf/1cfn_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1cfn ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
 The X-ray crystal structures of an anti-p24 (HIV-1) monoclonal antibody Fab fragment alone and in complexes with the epitope peptide GATPQDLNTnL (n = norleucine), an epitope-homologous peptide GATPEDLNQKLAGN, as well as two unrelated peptides GLYEWGGARITNTD and efslkGpllqwrsG (D-peptide), are presented to a maximum resolution of 2.6 A. The latter three peptides were identified from screening synthetic combinatorial peptide libraries. Although all peptides bind to the same antigen combining site, the nonhomologous peptides adopt different binding conformations and also form their critical contacts with different antibody residues. Only small readjustments are observed within the framework of the Fab fragment upon binding.
-==About this Structure==
+Crystallographic analysis of anti-p24 (HIV-1) monoclonal antibody cross-reactivity and polyspecificity.,Keitel T, Kramer A, Wessner H, Scholz C, Schneider-Mergener J, Hohne W Cell. 1997 Dec 12;91(6):811-20. PMID:9413990<ref>PMID:9413990</ref>
-Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CFN OCA].
-==Reference==
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-Crystallographic analysis of anti-p24 (HIV-1) monoclonal antibody cross-reactivity and polyspecificity., Keitel T, Kramer A, Wessner H, Scholz C, Schneider-Mergener J, Hohne W, Cell. 1997 Dec 12;91(6):811-20. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9413990 9413990]
+</div>
-[[Category: Hoehne, W.]]
+<div class="pdbe-citations 1cfn" style="background-color:#fffaf0;"></div>
-[[Category: Keitel, T.]]
+== References ==
-[[Category: Kramer, A.]]
+<references/>
-[[Category: Schneider-Mergener, J.]]
+__TOC__
-[[Category: Scholz, C.]]
+</StructureSection>
-[[Category: Wessner, H.]]
+[[Category: Large Structures]]
-[[Category: Cross reactivity]]
+[[Category: Mus musculus]]
-[[Category: Fab-fragment]]
+[[Category: Synthetic construct]]
-[[Category: Hiv-1]]
+[[Category: Hoehne W]]
-[[Category: Peptide]]
+[[Category: Keitel T]]
-[[Category: Polyspecificity]]
+[[Category: Kramer A]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 12:41:12 2008''
+[[Category: Schneider-Mergener J]]
+[[Category: Scholz C]]
+[[Category: Wessner H]]