1w6h: Difference between revisions

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-==NOVEL PLASMEPSIN II-INHIBITOR COMPLEX==
-<StructureSection load='1w6h' size='340' side='right' caption='[[1w6h]], [[Resolution|resolution]] 2.24&Aring;' scene=''>
+==Novel plasmepsin II-inhibitor complex==
+<StructureSection load='1w6h' size='340' side='right'caption='[[1w6h]], [[Resolution|resolution]] 2.24&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1w6h]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plafa Plafa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W6H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1W6H FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1w6h]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W6H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1W6H FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=TIT:N-((3S,4S)-5-[(4-BROMOBENZYL)OXY]-3-HYDROXY-4-{[N-(PYRIDIN-2-YLCARBONYL)-L-VALYL]AMINO}PENTANOYL)-L-ALANYL-L-LEUCINAMIDE'>TIT</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.24&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1j8j|1j8j]], [[1lee|1lee]], [[1lf2|1lf2]], [[1lf3|1lf3]], [[1lf4|1lf4]], [[1m43|1m43]], [[1me6|1me6]], [[1pfz|1pfz]], [[1sme|1sme]], [[1w6i|1w6i]], [[1xdh|1xdh]], [[1xe5|1xe5]], [[1xe6|1xe6]], [[2bju|2bju]], [[2bl3|2bl3]]</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TIT:N-((3S,4S)-5-[(4-BROMOBENZYL)OXY]-3-HYDROXY-4-{[N-(PYRIDIN-2-YLCARBONYL)-L-VALYL]AMINO}PENTANOYL)-L-ALANYL-L-LEUCINAMIDE'>TIT</scene></td></tr>
-<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Plasmepsin_II Plasmepsin II], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.39 3.4.23.39] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1w6h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w6h OCA], [https://pdbe.org/1w6h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1w6h RCSB], [https://www.ebi.ac.uk/pdbsum/1w6h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1w6h ProSAT]</span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w6h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w6h OCA], [http://pdbe.org/1w6h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1w6h RCSB], [http://www.ebi.ac.uk/pdbsum/1w6h PDBsum]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/PLM2_PLAFX PLM2_PLAFX] During the asexual blood stage, participates in initial cleavage of native host hemoglobin (Hb) resulting in Hb denaturation (PubMed:11782538, PubMed:15574427, PubMed:8844673). May cleave preferentially denatured hemoglobin that has been cleaved by PMI (PubMed:8844673). Digestion of host Hb is an essential step which provides the parasite with amino acids for protein synthesis, and regulates osmolarity (Probable).<ref>PMID:11782538</ref> <ref>PMID:15574427</ref> <ref>PMID:8844673</ref>
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
 Check<jmol>
    <jmolCheckbox>
-     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w6/1w6h_consurf.spt"</scriptWhenChecked>
+     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w6/1w6h_consurf.spt"</scriptWhenChecked>
-     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
      <text>to colour the structure by Evolutionary Conservation</text>
    </jmolCheckbox>
@@ Line 21: / Line 23: @@
 ==See Also==
 *[[Plasmepsin|Plasmepsin]]
+== References ==
+<references/>
 __TOC__
 </StructureSection>
-[[Category: Plafa]]
+[[Category: Large Structures]]
-[[Category: Plasmepsin II]]
+[[Category: Plasmodium falciparum]]
-[[Category: Johansson, P O]]
+[[Category: Johansson P-O]]
-[[Category: Kvarnstroem, I]]
+[[Category: Kvarnstroem I]]
-[[Category: Lindberg, J]]
+[[Category: Lindberg J]]
-[[Category: Rosenquist, A]]
+[[Category: Rosenquist A]]
-[[Category: Samuelsson, B]]
+[[Category: Samuelsson B]]
-[[Category: Unge, T]]
+[[Category: Unge T]]
-[[Category: Vrang, L]]
+[[Category: Vrang L]]
-[[Category: Aspartic protease]]
-[[Category: Drug]]
-[[Category: Glycoprotein]]
-[[Category: Hydrolase]]
-[[Category: Malaria]]
-[[Category: Plasmepsin]]