1w6h: Difference between revisions

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-[[Image:1w6h.gif|left|200px]]<br />
-<applet load="1w6h" size="450" color="white" frame="true" align="right" spinBox="true"
-caption="1w6h, resolution 2.24&Aring;" />
-'''NOVEL PLASMEPSIN II-INHIBITOR COMPLEX'''<br />
-==About this Structure==
+==Novel plasmepsin II-inhibitor complex==
-W6H is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]] with TIT as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/Plasmepsin_II Plasmepsin II]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.39 3.4.23.39]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1W6H OCA]].
+<StructureSection load='1w6h' size='340' side='right'caption='[[1w6h]], [[Resolution|resolution]] 2.24&Aring;' scene=''>
-[[Category: Plasmepsin II]]
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1w6h]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W6H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1W6H FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.24&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TIT:N-((3S,4S)-5-[(4-BROMOBENZYL)OXY]-3-HYDROXY-4-{[N-(PYRIDIN-2-YLCARBONYL)-L-VALYL]AMINO}PENTANOYL)-L-ALANYL-L-LEUCINAMIDE'>TIT</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1w6h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w6h OCA], [https://pdbe.org/1w6h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1w6h RCSB], [https://www.ebi.ac.uk/pdbsum/1w6h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1w6h ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/PLM2_PLAFX PLM2_PLAFX] During the asexual blood stage, participates in initial cleavage of native host hemoglobin (Hb) resulting in Hb denaturation (PubMed:11782538, PubMed:15574427, PubMed:8844673). May cleave preferentially denatured hemoglobin that has been cleaved by PMI (PubMed:8844673). Digestion of host Hb is an essential step which provides the parasite with amino acids for protein synthesis, and regulates osmolarity (Probable).<ref>PMID:11782538</ref> <ref>PMID:15574427</ref> <ref>PMID:8844673</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w6/1w6h_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1w6h ConSurf].
+<div style="clear:both"></div>
+==See Also==
+*[[Plasmepsin|Plasmepsin]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
 [[Category: Plasmodium falciparum]]
-[[Category: Single protein]]
+[[Category: Johansson P-O]]
-[[Category: Johansson, P.O.]]
+[[Category: Kvarnstroem I]]
-[[Category: Kvarnstroem, I.]]
+[[Category: Lindberg J]]
-[[Category: Lindberg, J.]]
+[[Category: Rosenquist A]]
-[[Category: Rosenquist, A.]]
+[[Category: Samuelsson B]]
-[[Category: Samuelsson, L.Vrang B.]]
+[[Category: Unge T]]
-[[Category: Unge, T.]]
+[[Category: Vrang L]]
-[[Category: TIT]]
-[[Category: aspartic protease]]
-[[Category: drug]]
-[[Category: glycoprotein]]
-[[Category: hydrolase]]
-[[Category: malaria]]
-[[Category: plasmepsin]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 16:26:28 2007''