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[[Image:2uvz.jpg|left|200px]]<br /><applet load="2uvz" size="350" color="white" frame="true" align="right" spinBox="true"
caption="2uvz, resolution 1.94&Aring;" />
'''STRUCTURE OF PKA-PKB CHIMERA COMPLEXED WITH C-PHENYL-C-(4-(9H-PURIN-6-YL)-PHENYL)-METHYLAMINE'''<br />


==About this Structure==
==Structure of PKA-PKB chimera complexed with C-Phenyl-C-(4-(9H-purin-6- yl)-phenyl)-methylamine==
2UVZ is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] with <scene name='pdbligand=GVJ:'>GVJ</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Site: <scene name='pdbsite=AC1:Gvj+Binding+Site+For+Chain+A'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UVZ OCA].  
<StructureSection load='2uvz' size='340' side='right'caption='[[2uvz]], [[Resolution|resolution]] 1.94&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2uvz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UVZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2UVZ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.94&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GVJ:(S)-1-PHENYL-1-[4-(9H-PURIN-6-YL)PHENYL]METHANAMINE'>GVJ</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2uvz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uvz OCA], [https://pdbe.org/2uvz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2uvz RCSB], [https://www.ebi.ac.uk/pdbsum/2uvz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2uvz ProSAT]</span></td></tr>
</table>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uv/2uvz_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2uvz ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
6-phenylpurines were identified as novel, ATP-competitive inhibitors of protein kinase B (PKB/Akt) from a fragment-based screen and were rapidly progressed to potent compounds using iterative protein-ligand crystallography with a PKA-PKB chimeric protein. An elaborated lead compound showed cell growth inhibition and effects on cellular signaling pathways characteristic of PKB inhibition.
 
Rapid evolution of 6-phenylpurine inhibitors of protein kinase B through structure-based design.,Donald A, McHardy T, Rowlands MG, Hunter LJ, Davies TG, Berdini V, Boyle RG, Aherne GW, Garrett MD, Collins I J Med Chem. 2007 May 17;50(10):2289-92. Epub 2007 Apr 24. PMID:17451235<ref>PMID:17451235</ref>
 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 2uvz" style="background-color:#fffaf0;"></div>
 
==See Also==
*[[CAMP-dependent protein kinase 3D structures|CAMP-dependent protein kinase 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Bos taurus]]
[[Category: Bos taurus]]
[[Category: Protein complex]]
[[Category: Homo sapiens]]
[[Category: Aherne, G W.]]
[[Category: Large Structures]]
[[Category: Boyle, R G.]]
[[Category: Aherne GW]]
[[Category: Collins, I.]]
[[Category: Boyle RG]]
[[Category: Davies, T G.]]
[[Category: Collins I]]
[[Category: Donald, A.]]
[[Category: Davies TG]]
[[Category: Garrett, M D.]]
[[Category: Donald A]]
[[Category: Hunter, L J.]]
[[Category: Garrett MD]]
[[Category: Mchardy, T.]]
[[Category: Hunter LJ]]
[[Category: Rowlands, M G.]]
[[Category: McHardy T]]
[[Category: GVJ]]
[[Category: Rowlands MG]]
[[Category: atp-binding]]
[[Category: camp]]
[[Category: kinase]]
[[Category: lipoprotein]]
[[Category: myristate]]
[[Category: nuclear protein]]
[[Category: nucleotide-binding]]
[[Category: phosphorylation]]
[[Category: protein kinase inhibitor]]
[[Category: serine/threonine-protein kinase]]
[[Category: transferase]]
[[Category: transferase/inhibitor complex]]
 
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