1oay: Difference between revisions

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-{{Seed}}
-[[Image:1oay.png|left|200px]]
-<!--
+==Antibody multispecificity mediated by conformational diversity==
-The line below this paragraph, containing "STRUCTURE_1oay", creates the "Structure Box" on the page.
+<StructureSection load='1oay' size='340' side='right'caption='[[1oay]], [[Resolution|resolution]] 2.66&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1oay]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OAY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OAY FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.66&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FUR:FURAZOLIDONE'>FUR</scene></td></tr>
-{{STRUCTURE_1oay|  PDB=1oay  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1oay FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oay OCA], [https://pdbe.org/1oay PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1oay RCSB], [https://www.ebi.ac.uk/pdbsum/1oay PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1oay ProSAT]</span></td></tr>
+</table>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oa/1oay_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1oay ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+A single antibody was shown to adopt different binding-site conformations and thereby bind unrelated antigens. Analysis by both x-ray crystallography and pre-steady-state kinetics revealed an equilibrium between different preexisting isomers, one of which possessed a promiscuous, low-affinity binding site for aromatic ligands, including the immunizing hapten. A subsequent induced-fit isomerization led to high-affinity complexes with a deep and narrow binding site. A protein antigen identified by repertoire selection made use of an unrelated antibody isomer with a wide, shallow binding site. Conformational diversity, whereby one sequence adopts multiple structures and multiple functions, can increase the effective size of the antibody repertoire but may also lead to autoimmunity and allergy.
-===ANTIBODY MULTISPECIFICITY MEDIATED BY CONFORMATIONAL DIVERSITY===
+Antibody multispecificity mediated by conformational diversity.,James LC, Roversi P, Tawfik DS Science. 2003 Feb 28;299(5611):1362-7. PMID:12610298<ref>PMID:12610298</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-<!--
+</div>
-The line below this paragraph, {{ABSTRACT_PUBMED_12610298}}, adds the Publication Abstract to the page
+<div class="pdbe-citations 1oay" style="background-color:#fffaf0;"></div>
-(as it appears on PubMed at http://www.pubmed.gov), where 12610298 is the PubMed ID number.
+== References ==
--->
+<references/>
-{{ABSTRACT_PUBMED_12610298}}
+__TOC__
+</StructureSection>
-==About this Structure==
+[[Category: Large Structures]]
-OAY is a 6 chains structure of sequences from [http://en.wikipedia.org/wiki/Rattus_rattus Rattus rattus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OAY OCA].
+[[Category: Mus musculus]]
+[[Category: James LC]]
-==Reference==
+[[Category: Roversi P]]
-<ref group="xtra">PMID:12610298</ref><references group="xtra"/>
+[[Category: Tawfik D]]
-[[Category: Rattus rattus]]
-[[Category: James, L C.]]
-[[Category: Roversi, P.]]
-[[Category: Tawfik, D.]]
-[[Category: Allergy]]
-[[Category: Antibody]]
-[[Category: Conformational diversity]]
-[[Category: Ige]]
-[[Category: Multispecificity]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 03:54:51 2009''