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== | |||
<StructureSection load='2c6q' size='340' side='right' caption='[[2c6q]], [[Resolution|resolution]] 1.70Å' scene=''> | ==Crystal structure of human guanosine monophosphate reductase 2 GMPR2 in complex with IMP and NADPH== | ||
<StructureSection load='2c6q' size='340' side='right'caption='[[2c6q]], [[Resolution|resolution]] 1.70Å' scene=''> | |||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2c6q]] is a 8 chain structure with sequence from [ | <table><tr><td colspan='2'>[[2c6q]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C6Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2C6Q FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IMP:INOSINIC+ACID'>IMP</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c6q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c6q OCA], [https://pdbe.org/2c6q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c6q RCSB], [https://www.ebi.ac.uk/pdbsum/2c6q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c6q ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/GMPR2_HUMAN GMPR2_HUMAN] Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. Plays a role in modulating cellular differentiation.<ref>PMID:12009299</ref> <ref>PMID:12669231</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c6/2c6q_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c6/2c6q_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/ | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2c6q ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 2c6q" style="background-color:#fffaf0;"></div> | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Arrowsmith | [[Category: Large Structures]] | ||
[[Category: Berglund | [[Category: Arrowsmith C]] | ||
[[Category: Edwards | [[Category: Berglund H]] | ||
[[Category: Ehn | [[Category: Edwards A]] | ||
[[Category: Graslund | [[Category: Ehn M]] | ||
[[Category: Hallberg | [[Category: Graslund S]] | ||
[[Category: Hammarstrom | [[Category: Hallberg BM]] | ||
[[Category: Kotenyova | [[Category: Hammarstrom M]] | ||
[[Category: Kursula | [[Category: Kotenyova T]] | ||
[[Category: Nilsson-Ehle | [[Category: Kursula P]] | ||
[[Category: Nordlund | [[Category: Nilsson-Ehle P]] | ||
[[Category: Ogg | [[Category: Nordlund P]] | ||
[[Category: Persson | [[Category: Ogg D]] | ||
[[Category: Sagemark | [[Category: Persson C]] | ||
[[Category: Schuler | [[Category: Sagemark J]] | ||
[[Category: Stenmark | [[Category: Schuler H]] | ||
[[Category: Sundstrom | [[Category: Stenmark P]] | ||
[[Category: Thorsell | [[Category: Sundstrom M]] | ||
[[Category: Weigelt | [[Category: Thorsell A]] | ||
[[Category: Weigelt J]] | |||