1a8b: Difference between revisions

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-[[Image:1a8b.gif|left|200px]]<br />
-<applet load="1a8b" size="450" color="white" frame="true" align="right" spinBox="true"
-caption="1a8b, resolution 1.9&Aring;" />
-'''RAT ANNEXIN V COMPLEXED WITH GLYCEROPHOSPHOETHANOLAMINE'''<br />
-==Overview==
+==RAT ANNEXIN V COMPLEXED WITH GLYCEROPHOSPHOETHANOLAMINE==
-Structural evidence is presented for a 'Ca(2+)-bridging' mechanism, proposed for Ca(2+)-binding interfacial membrane proteins such as, annexins, protein kinase C, and certain coagulation proteins. Crystal, structures of Ca(2+)-annexin V complexes with phospholipid polar heads, provide molecular details of 'Ca(2+)-bridges' as key features in the, membrane attachment exhibited by these proteins. Distinct binding sites, for phospholipid head groups are observed, including a novel, double-Ca2+, recognition site for phosphoserine that may serve as a phosphatidylserine, receptor site in vivo.
+<StructureSection load='1a8b' size='340' side='right'caption='[[1a8b]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1a8b]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A8B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1A8B FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GPE:L-ALPHA-GLYCEROPHOSPHORYLETHANOLAMINE'>GPE</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1a8b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a8b OCA], [https://pdbe.org/1a8b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1a8b RCSB], [https://www.ebi.ac.uk/pdbsum/1a8b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1a8b ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/ANXA5_RAT ANXA5_RAT] This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a8/1a8b_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1a8b ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Structural evidence is presented for a 'Ca(2+)-bridging' mechanism, proposed for Ca(2+)-binding interfacial membrane proteins such as annexins, protein kinase C, and certain coagulation proteins. Crystal structures of Ca(2+)-annexin V complexes with phospholipid polar heads provide molecular details of 'Ca(2+)-bridges' as key features in the membrane attachment exhibited by these proteins. Distinct binding sites for phospholipid head groups are observed, including a novel, double-Ca2+ recognition site for phosphoserine that may serve as a phosphatidylserine receptor site in vivo.
-==About this Structure==
+Ca(2+)-bridging mechanism and phospholipid head group recognition in the membrane-binding protein annexin V.,Swairjo MA, Concha NO, Kaetzel MA, Dedman JR, Seaton BA Nat Struct Biol. 1995 Nov;2(11):968-74. PMID:7583670<ref>PMID:7583670</ref>
-A8B is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with CA and GPE as [http://en.wikipedia.org/wiki/ligands ligands]. Structure known Active Site: GPE. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1A8B OCA].
-==Reference==
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-Ca(2+)-bridging mechanism and phospholipid head group recognition in the membrane-binding protein annexin V., Swairjo MA, Concha NO, Kaetzel MA, Dedman JR, Seaton BA, Nat Struct Biol. 1995 Nov;2(11):968-74. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=7583670 7583670]
+</div>
+<div class="pdbe-citations 1a8b" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Annexin 3D structures|Annexin 3D structures]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
 [[Category: Rattus norvegicus]]
-[[Category: Single protein]]
+[[Category: Concha NO]]
-[[Category: Concha, N.O.]]
+[[Category: Dedman JR]]
-[[Category: Dedman, J.R.]]
+[[Category: Kaetzel MA]]
-[[Category: Kaetzel, M.A.]]
+[[Category: Seaton BA]]
-[[Category: Seaton, B.A.]]
+[[Category: Swairjo MA]]
-[[Category: Swairjo, M.A.]]
-[[Category: CA]]
-[[Category: GPE]]
-[[Category: calcium binding protein]]
-[[Category: membrane binding protein]]
-[[Category: phospholipid analog]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov  5 13:04:27 2007''