1e81: Difference between revisions

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[[Image:1e81.gif|left|200px]]<br />
<applet load="1e81" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1e81, resolution 2.05&Aring;" />
'''ENDOTHIAPEPSIN COMPLEX WITH RENIN INHIBITOR MERCK-KGAA-EMD61395'''<br />


==About this Structure==
==Endothiapepsin complex with renin inhibitor MERCK-KGAA-EMD61395==
1E81 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Cryphonectria_parasitica Cryphonectria parasitica] with MRM as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Mucorpepsin Mucorpepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.23 3.4.23.23] Structure known Active Site: CAT. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1E81 OCA].  
<StructureSection load='1e81' size='340' side='right'caption='[[1e81]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1e81]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Cryphonectria_parasitica Cryphonectria parasitica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E81 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1E81 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=M91:(2S)-1-{[(2R)-1-{[(2S,3S)-1-CYCLOHEXYL-3-HYDROXY-4-(2-OXOPYRIDIN-1(2H)-YL)BUTAN-2-YL]AMINO}-3-(METHYLSULFANYL)-1-OXOPROPAN-2-YL]AMINO}-1-OXO-3-PHENYLPROPAN-2-YL+4-AMINOPIPERIDINE-1-CARBOXYLATE'>M91</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1e81 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e81 OCA], [https://pdbe.org/1e81 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1e81 RCSB], [https://www.ebi.ac.uk/pdbsum/1e81 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1e81 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CARP_CRYPA CARP_CRYPA]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e8/1e81_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1e81 ConSurf].
<div style="clear:both"></div>
 
==See Also==
*[[Pepsin|Pepsin]]
__TOC__
</StructureSection>
[[Category: Cryphonectria parasitica]]
[[Category: Cryphonectria parasitica]]
[[Category: Mucorpepsin]]
[[Category: Large Structures]]
[[Category: Single protein]]
[[Category: Cooper JB]]
[[Category: Cooper, J.B.]]
[[Category: Raddatz P]]
[[Category: Raddatz, P.]]
[[Category: Read JA]]
[[Category: Read, J.A.]]
[[Category: Rippmann F]]
[[Category: Rippmann, F.]]
[[Category: Toldo L]]
[[Category: Toldo, L.]]
[[Category: MRM]]
[[Category: hydrolase (acid proteinase)]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov  5 13:03:06 2007''

Latest revision as of 10:21, 23 October 2024

Endothiapepsin complex with renin inhibitor MERCK-KGAA-EMD61395Endothiapepsin complex with renin inhibitor MERCK-KGAA-EMD61395

Structural highlights

1e81 is a 1 chain structure with sequence from Cryphonectria parasitica. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.05Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

CARP_CRYPA

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

1e81, resolution 2.05Å

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