1gzr: Difference between revisions

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 ==Human Insulin-like growth factor; ESRF data==
-<StructureSection load='1gzr' size='340' side='right' caption='[[1gzr]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
+<StructureSection load='1gzr' size='340' side='right'caption='[[1gzr]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1gzr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GZR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GZR FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1gzr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GZR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GZR FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C15:N-DODECYL-N,N-DIMETHYL-3-AMMONIO-1-PROPANESULFONATE'>C15</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1gzy|1gzy]], [[1gzz|1gzz]], [[1h02|1h02]], [[1h59|1h59]], [[1imx|1imx]], [[2gf1|2gf1]], [[3gf1|3gf1]]</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C15:N-DODECYL-N,N-DIMETHYL-3-AMMONIO-1-PROPANESULFONATE'>C15</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gzr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gzr OCA], [http://pdbe.org/1gzr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1gzr RCSB], [http://www.ebi.ac.uk/pdbsum/1gzr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1gzr ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gzr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gzr OCA], [https://pdbe.org/1gzr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gzr RCSB], [https://www.ebi.ac.uk/pdbsum/1gzr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gzr ProSAT]</span></td></tr>
 </table>
 == Disease ==
-[[http://www.uniprot.org/uniprot/IGF1_HUMAN IGF1_HUMAN]] Defects in IGF1 are the cause of insulin-like growth factor I deficiency (IGF1 deficiency) [MIM:[http://omim.org/entry/608747 608747]]. IGF1 deficiency is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness and mental retardation.
+[https://www.uniprot.org/uniprot/IGF1_HUMAN IGF1_HUMAN] Defects in IGF1 are the cause of insulin-like growth factor I deficiency (IGF1 deficiency) [MIM:[https://omim.org/entry/608747 608747]. IGF1 deficiency is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness and mental retardation.
 == Function ==
-[[http://www.uniprot.org/uniprot/IGF1_HUMAN IGF1_HUMAN]] The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake.<ref>PMID:21076856</ref>
+[https://www.uniprot.org/uniprot/IGF1_HUMAN IGF1_HUMAN] The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake.<ref>PMID:21076856</ref>
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 17: / Line 17: @@
    <jmolCheckbox>
      <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gz/1gzr_consurf.spt"</scriptWhenChecked>
-     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
      <text>to colour the structure by Evolutionary Conservation</text>
    </jmolCheckbox>
@@ Line 33: / Line 33: @@
 ==See Also==
-*[[IGF1|IGF1]]
+*[[Insulin-like growth factor|Insulin-like growth factor]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Human]]
+[[Category: Homo sapiens]]
-[[Category: Bree, F M.De]]
+[[Category: Large Structures]]
-[[Category: Brzozowski, A M]]
+[[Category: Brzozowski AM]]
-[[Category: Dauter, Z]]
+[[Category: Dauter Z]]
-[[Category: Dodson, E J]]
+[[Category: De Bree FM]]
-[[Category: Dodson, G G]]
+[[Category: Dodson EJ]]
-[[Category: Murshudov, G]]
+[[Category: Dodson GG]]
-[[Category: Turkenburg, J P]]
+[[Category: Murshudov G]]
-[[Category: Verma, C]]
+[[Category: Turkenburg JP]]
-[[Category: Growth factor]]
+[[Category: Verma C]]
-[[Category: Igf-1]]
-[[Category: Insulin family]]
-[[Category: Plasma]]