1awb: Difference between revisions

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-[[Image:1awb.gif|left|200px]]<br />
-<applet load="1awb" size="450" color="white" frame="true" align="right" spinBox="true"
-caption="1awb, resolution 2.50&Aring;" />
-'''HUMAN MYO-INOSITOL MONOPHOSPHATASE IN COMPLEX WITH D-INOSITOL-1-PHOSPHATE AND CALCIUM'''<br />
-==About this Structure==
+==HUMAN MYO-INOSITOL MONOPHOSPHATASE IN COMPLEX WITH D-INOSITOL-1-PHOSPHATE AND CALCIUM==
-AWB is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with CA, CL and IPD as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Inositol-phosphate_phosphatase Inositol-phosphate phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.25 3.1.3.25] Structure known Active Sites: CA1, CA2, CA3, CA4, CA5 and CA6. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1AWB OCA].
+<StructureSection load='1awb' size='340' side='right'caption='[[1awb]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1awb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AWB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AWB FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=IPD:D-MYO-INOSITOL-1-PHOSPHATE'>IPD</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1awb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1awb OCA], [https://pdbe.org/1awb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1awb RCSB], [https://www.ebi.ac.uk/pdbsum/1awb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1awb ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/IMPA1_HUMAN IMPA1_HUMAN] Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides and has been implicated as the pharmacological target for lithium action in brain. Can use myo-inositol monophosphates, myo-inositol 1,3-diphosphate, myo-inositol 1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates.<ref>PMID:17068342</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/aw/1awb_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1awb ConSurf].
+<div style="clear:both"></div>
+==See Also==
+*[[Inositol monophosphatase 3D structures|Inositol monophosphatase 3D structures]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Inositol-phosphate phosphatase]]
+[[Category: Large Structures]]
-[[Category: Single protein]]
+[[Category: Ganzhorn AJ]]
-[[Category: Ganzhorn, A.J.]]
+[[Category: Pelton PD]]
-[[Category: Pelton, P.D.]]
+[[Category: Rondeau J-M]]
-[[Category: Rondeau, J.M.]]
+[[Category: Vincendon P]]
-[[Category: Vincendon, P.]]
-[[Category: CA]]
-[[Category: CL]]
-[[Category: IPD]]
-[[Category: hydrolase]]
-[[Category: myo-inositol]]
-[[Category: phosphatase]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 16:02:50 2007''