3ce1: Difference between revisions

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-[[Image:3ce1.png|left|200px]]
-{{STRUCTURE_3ce1|  PDB=3ce1  |  SCENE=  }}
+==Crystal Structure of the Cu/Zn Superoxide Dismutase from Cryptococcus liquefaciens Strain N6==
+<StructureSection load='3ce1' size='340' side='right'caption='[[3ce1]], [[Resolution|resolution]] 1.20&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[3ce1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Naganishia_liquefaciens Naganishia liquefaciens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CE1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CE1 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.2&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ce1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ce1 OCA], [https://pdbe.org/3ce1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ce1 RCSB], [https://www.ebi.ac.uk/pdbsum/3ce1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ce1 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/A0ZPR9_9TREE A0ZPR9_9TREE] Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity).[RuleBase:RU000393]
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ce/3ce1_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ce1 ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+The deep-sea yeast Cryptococcus liquefaciens strain N6 shows high tolerance towards heavy metals, and can grow in the presence of high concentrations of copper ions. Enzymatic analysis indicated that copper ions induced the Cu/Zn superoxide dismutase activity of strain N6 (Cl-SOD1). In this study, the 1.2A resolution crystal structure of Cl-SOD1 has revealed several significant residue substitutions compared to the other Cu/Zn SODs. In the electrostatic loop, notably, His135 and Pro136 replace the well-conserved linear residues, while Thr133 substitutes a highly conserved glycine. The electrostatic loop has been shown to be involved in the copper uptake process, and these substitutions have caused an inward dragging of the turn region of the loop. As the introduction of proline and abolishment of glycine decrease loop flexibility, this structural reorganization may have helped stabilize the loop conformation, possibly resulting in more efficient copper uptake and a more stabilized copper-bound form.
-===Crystal Structure of the Cu/Zn Superoxide Dismutase from Cryptococcus liquefaciens Strain N6===
+Structure of Cu/Zn superoxide dismutase from the heavy-metal-tolerant yeast Cryptococcus liquefaciens strain N6.,Teh AH, Kanamasa S, Kajiwara S, Kumasaka T Biochem Biophys Res Commun. 2008 Sep 26;374(3):475-8. Epub 2008 Jul 18. PMID:18640099<ref>PMID:18640099</ref>
-{{ABSTRACT_PUBMED_18640099}}
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
-==About this Structure==
+<div class="pdbe-citations 3ce1" style="background-color:#fffaf0;"></div>
-[[3ce1]] is a 1 chain structure of [[Superoxide Dismutase]] with sequence from [http://en.wikipedia.org/wiki/Cryptococcus_liquefaciens Cryptococcus liquefaciens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CE1 OCA].
 ==See Also==
-*[[Superoxide Dismutase|Superoxide Dismutase]]
+*[[Superoxide dismutase 3D structures|Superoxide dismutase 3D structures]]
+== References ==
-==Reference==
+<references/>
-<ref group="xtra">PMID:018640099</ref><references group="xtra"/>
+__TOC__
-[[Category: Cryptococcus liquefaciens]]
+</StructureSection>
-[[Category: Superoxide dismutase]]
+[[Category: Large Structures]]
-[[Category: Kajiwara, S.]]
+[[Category: Naganishia liquefaciens]]
-[[Category: Kanamasa, S.]]
+[[Category: Kajiwara S]]
-[[Category: Kumasaka, T.]]
+[[Category: Kanamasa S]]
-[[Category: Teh, A H.]]
+[[Category: Kumasaka T]]
-[[Category: Antioxidant]]
+[[Category: Teh AH]]
-[[Category: Greek-key beta barrel]]
-[[Category: Metal-binding]]
-[[Category: Oxidoreductase]]