2w2s: Difference between revisions

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-{{Seed}}
-[[Image:2w2s.jpg|left|200px]]
-<!--
+==Structure of the Lagos bat virus matrix protein==
-The line below this paragraph, containing "STRUCTURE_2w2s", creates the "Structure Box" on the page.
+<StructureSection load='2w2s' size='340' side='right'caption='[[2w2s]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[2w2s]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lagos_bat_lyssavirus Lagos bat lyssavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W2S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2W2S FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.75&#8491;</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2w2s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w2s OCA], [https://pdbe.org/2w2s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2w2s RCSB], [https://www.ebi.ac.uk/pdbsum/2w2s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2w2s ProSAT]</span></td></tr>
-{{STRUCTURE_2w2s|  PDB=2w2s  |  SCENE=  }}
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/MATRX_LBV MATRX_LBV] Plays a major role in assembly and budding of virion. Completely covers the ribonucleoprotein coil and keep it in condensed bullet-shaped form. Inhibits viral transcription and stimulates replication. Plays a major role in early induction of TRAIL-mediated apoptosis in infected neurons (By similarity).
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w2/2w2s_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2w2s ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+The matrix (M) proteins of rhabdoviruses are multifunctional proteins essential for virus maturation and budding that also regulate the expression of viral and host proteins. We have solved the structures of M from the vesicular stomatitis virus serotype New Jersey (genus: Vesiculovirus) and from Lagos bat virus (genus: Lyssavirus), revealing that both share a common fold despite sharing no identifiable sequence homology. Strikingly, in both structures a stretch of residues from the otherwise-disordered N terminus of a crystallographically adjacent molecule is observed binding to a hydrophobic cavity on the surface of the protein, thereby forming non-covalent linear polymers of M in the crystals. While the overall topology of the interaction is conserved between the two structures, the molecular details of the interactions are completely different. The observed interactions provide a compelling model for the flexible self-assembly of the matrix protein during virion morphogenesis and may also modulate interactions with host proteins.
-===STRUCTURE OF THE LAGOS BAT VIRUS MATRIX PROTEIN===
+Rhabdovirus matrix protein structures reveal a novel mode of self-association.,Graham SC, Assenberg R, Delmas O, Verma A, Gholami A, Talbi C, Owens RJ, Stuart DI, Grimes JM, Bourhy H PLoS Pathog. 2008 Dec;4(12):e1000251. Epub 2008 Dec 26. PMID:19112510<ref>PMID:19112510</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-<!--
+</div>
-The line below this paragraph, {{ABSTRACT_PUBMED_19112510}}, adds the Publication Abstract to the page
+<div class="pdbe-citations 2w2s" style="background-color:#fffaf0;"></div>
-(as it appears on PubMed at http://www.pubmed.gov), where 19112510 is the PubMed ID number.
+== References ==
--->
+<references/>
-{{ABSTRACT_PUBMED_19112510}}
+__TOC__
+</StructureSection>
-==About this Structure==
+[[Category: Lagos bat lyssavirus]]
-W2S is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Lagos_bat_virus Lagos bat virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W2S OCA].
+[[Category: Large Structures]]
+[[Category: Assenberg R]]
-==Reference==
+[[Category: Bourhy H]]
-Rhabdovirus matrix protein structures reveal a novel mode of self-association., Graham SC, Assenberg R, Delmas O, Verma A, Gholami A, Talbi C, Owens RJ, Stuart DI, Grimes JM, Bourhy H, PLoS Pathog. 2008 Dec;4(12):e1000251. Epub 2008 Dec 26. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/19112510 19112510]
+[[Category: Delmas O]]
+[[Category: Gholami A]]
-Expression, purification and crystallization of a lyssavirus matrix (M) protein., Assenberg R, Delmas O, Graham SC, Verma A, Berrow N, Stuart DI, Owens RJ, Bourhy H, Grimes JM, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Apr 1;64(Pt, 4):258-62. Epub 2008 Mar 21. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18391421 18391421]
+[[Category: Graham SC]]
-[[Category: Lagos bat virus]]
+[[Category: Grimes JM]]
-[[Category: Assenberg, R.]]
+[[Category: Owens RJ]]
-[[Category: Bourhy, H.]]
+[[Category: Stuart DI]]
-[[Category: Delmas, O.]]
+[[Category: Talbi C]]
-[[Category: Gholami, A.]]
+[[Category: Verma A]]
-[[Category: Graham, S C.]]
-[[Category: Grimes, J M.]]
-[[Category: Owens, R J.]]
-[[Category: Stuart, D I.]]
-[[Category: Talbi, C.]]
-[[Category: Verma, A.]]
-[[Category: Lagos bat virus]]
-[[Category: Matrix protein]]
-[[Category: Polymer]]
-[[Category: Viral assembly]]
-[[Category: Viral morphogenesis]]
-[[Category: Viral protein]]
-[[Category: Vsv]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 14 13:13:53 2009''