2w2s: Difference between revisions
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<StructureSection load='2w2s' size='340' side='right' caption='[[2w2s]], [[Resolution|resolution]] 2.75Å' scene=''> | ==Structure of the Lagos bat virus matrix protein== | ||
<StructureSection load='2w2s' size='340' side='right'caption='[[2w2s]], [[Resolution|resolution]] 2.75Å' scene=''> | |||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2w2s]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[2w2s]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lagos_bat_lyssavirus Lagos bat lyssavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W2S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2W2S FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.75Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2w2s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w2s OCA], [https://pdbe.org/2w2s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2w2s RCSB], [https://www.ebi.ac.uk/pdbsum/2w2s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2w2s ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/MATRX_LBV MATRX_LBV] Plays a major role in assembly and budding of virion. Completely covers the ribonucleoprotein coil and keep it in condensed bullet-shaped form. Inhibits viral transcription and stimulates replication. Plays a major role in early induction of TRAIL-mediated apoptosis in infected neurons (By similarity). | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w2/2w2s_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w2/2w2s_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/ | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2w2s ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 2w2s" style="background-color:#fffaf0;"></div> | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Lagos bat | [[Category: Lagos bat lyssavirus]] | ||
[[Category: Assenberg | [[Category: Large Structures]] | ||
[[Category: Bourhy | [[Category: Assenberg R]] | ||
[[Category: Delmas | [[Category: Bourhy H]] | ||
[[Category: Gholami | [[Category: Delmas O]] | ||
[[Category: Graham | [[Category: Gholami A]] | ||
[[Category: Grimes | [[Category: Graham SC]] | ||
[[Category: Owens | [[Category: Grimes JM]] | ||
[[Category: Stuart | [[Category: Owens RJ]] | ||
[[Category: Talbi | [[Category: Stuart DI]] | ||
[[Category: Verma | [[Category: Talbi C]] | ||
[[Category: Verma A]] | |||