2vrl: Difference between revisions

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<StructureSection load='2vrl' size='340' side='right'caption='[[2vrl]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
<StructureSection load='2vrl' size='340' side='right'caption='[[2vrl]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2vrl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VRL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VRL FirstGlance]. <br>
<table><tr><td colspan='2'>[[2vrl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VRL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VRL FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=MBN:TOLUENE'>MBN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2c67|2c67]], [[1oja|1oja]], [[2v5z|2v5z]], [[1s3e|1s3e]], [[2c73|2c73]], [[1ojb|1ojb]], [[2v60|2v60]], [[2byb|2byb]], [[2c65|2c65]], [[2c64|2c64]], [[1oj9|1oj9]], [[1ojd|1ojd]], [[1s3b|1s3b]], [[2c66|2c66]], [[2bk4|2bk4]], [[2bk5|2bk5]], [[2c70|2c70]], [[1h8r|1h8r]], [[2c75|2c75]], [[2bk3|2bk3]], [[2v61|2v61]], [[2c72|2c72]], [[1s2y|1s2y]], [[1gos|1gos]], [[1s2q|1s2q]], [[2c76|2c76]], [[1ojc|1ojc]], [[2vrm|2vrm]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=MBN:TOLUENE'>MBN</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Monoamine_oxidase Monoamine oxidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.4.3.4 1.4.3.4] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vrl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vrl OCA], [https://pdbe.org/2vrl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vrl RCSB], [https://www.ebi.ac.uk/pdbsum/2vrl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vrl ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vrl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vrl OCA], [https://pdbe.org/2vrl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vrl RCSB], [https://www.ebi.ac.uk/pdbsum/2vrl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vrl ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/AOFB_HUMAN AOFB_HUMAN]] Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine.  
[https://www.uniprot.org/uniprot/AOFB_HUMAN AOFB_HUMAN] Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vr/2vrl_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vr/2vrl_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Monoamine oxidase]]
[[Category: Binda C]]
[[Category: Binda, C]]
[[Category: Edmondson DE]]
[[Category: Edmondson, D E]]
[[Category: Hubalek F]]
[[Category: Hubalek, F]]
[[Category: Li M]]
[[Category: Li, M]]
[[Category: Mattevi A]]
[[Category: Mattevi, A]]
[[Category: Wang J]]
[[Category: Wang, J]]
[[Category: Acetylation]]
[[Category: Fad]]
[[Category: Flavin]]
[[Category: Flavoprotein]]
[[Category: Hydrazine]]
[[Category: Inhibitor binding]]
[[Category: Membrane]]
[[Category: Membrane protein]]
[[Category: Mitochondrion]]
[[Category: Oxidoreductase]]
[[Category: Transmembrane]]

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