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==crystal structure of Natratoxin, a snake sPLA2 that blocks A-type K+ channel==
==crystal structure of Natratoxin, a snake sPLA2 that blocks A-type K+ channel==
<StructureSection load='2osh' size='340' side='right' caption='[[2osh]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
<StructureSection load='2osh' size='340' side='right'caption='[[2osh]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2osh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Chinese_cobra Chinese cobra]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OSH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2OSH FirstGlance]. <br>
<table><tr><td colspan='2'>[[2osh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Naja_atra Naja atra]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OSH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OSH FirstGlance]. <br>
</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2osh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2osh OCA], [http://pdbe.org/2osh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2osh RCSB], [http://www.ebi.ac.uk/pdbsum/2osh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2osh ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2osh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2osh OCA], [https://pdbe.org/2osh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2osh RCSB], [https://www.ebi.ac.uk/pdbsum/2osh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2osh ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/PA2A1_NAJAT PA2A1_NAJAT]] Snake venom phospholipase A2 (PLA2) that has high affinity for muscarinic acetylcholine receptors mAChRs (CHRM) and has the ability to activate them. In guinea-pig ileum, produces an onset and dose-dependent contraction. Has also weak anticoagulant activity. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.<ref>PMID:18281071</ref> <ref>PMID:3117784</ref> 
[https://www.uniprot.org/uniprot/PA2A_NAJAT PA2A_NAJAT]  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/os/2osh_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/os/2osh_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
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==See Also==
==See Also==
*[[Phospholipase A2|Phospholipase A2]]
*[[Phospholipase A2 3D structures|Phospholipase A2 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Chinese cobra]]
[[Category: Large Structures]]
[[Category: Sun, L]]
[[Category: Naja atra]]
[[Category: Teng, M K]]
[[Category: Sun L]]
[[Category: A-type k+ channel inhibitor]]
[[Category: Teng MK]]
[[Category: Hydrolase]]
[[Category: Naja atra venom]]
[[Category: Phospholipase a2]]

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