2ja4: Difference between revisions

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-{{Seed}}
-[[Image:2ja4.png|left|200px]]
-<!--
+==Crystal structure of CD5 domain III reveals the fold of a group B scavenger cysteine-rich receptor==
-The line below this paragraph, containing "STRUCTURE_2ja4", creates the "Structure Box" on the page.
+<StructureSection load='2ja4' size='340' side='right'caption='[[2ja4]], [[Resolution|resolution]] 2.21&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[2ja4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JA4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JA4 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.21&#8491;</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ja4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ja4 OCA], [https://pdbe.org/2ja4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ja4 RCSB], [https://www.ebi.ac.uk/pdbsum/2ja4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ja4 ProSAT]</span></td></tr>
-{{STRUCTURE_2ja4|  PDB=2ja4  |  SCENE=  }}
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/CD5_HUMAN CD5_HUMAN] May act as a receptor in regulating T-cell proliferation.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ja/2ja4_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ja4 ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Scavenger receptor cysteine-rich (SRCR) domains are ancient protein modules widely found among cell surface and secreted proteins of the innate and adaptive immune system, where they mediate ligand binding. We have solved the crystal structure at 2.2 A of resolution of the SRCR CD5 domain III, a human lymphocyte receptor involved in the modulation of antigen specific receptor-mediated T cell activation and differentiation signals. The first structure of a member of a group B SRCR domain reveals the fold of this ancient protein module into a central core formed by two antiparallel beta-sheets and one alpha-helix, illustrating the conserved core at the protein level of genes coding for group A and B members of the SRCR superfamily. The novel SRCR group B structure permits the interpretation of site-directed mutagenesis data on the binding of activated leukocyte cell adhesion molecule (ALCAM/CD166) binding to CD6, a closely related lymphocyte receptor homologue to CD5.
-===CRYSTAL STRUCTURE OF CD5 DOMAIN III REVEALS THE FOLD OF A GROUP B SCAVENGER CYSTEINE-RICH RECEPTOR===
+Crystal structure of the third extracellular domain of CD5 reveals the fold of a group B scavenger cysteine-rich receptor domain.,Rodamilans B, Munoz IG, Bragado-Nilsson E, Sarrias MR, Padilla O, Blanco FJ, Lozano F, Montoya G J Biol Chem. 2007 Apr 27;282(17):12669-77. Epub 2007 Feb 23. PMID:17322294<ref>PMID:17322294</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-<!--
+</div>
-The line below this paragraph, {{ABSTRACT_PUBMED_17322294}}, adds the Publication Abstract to the page
+<div class="pdbe-citations 2ja4" style="background-color:#fffaf0;"></div>
-(as it appears on PubMed at http://www.pubmed.gov), where 17322294 is the PubMed ID number.
+== References ==
--->
+<references/>
-{{ABSTRACT_PUBMED_17322294}}
+__TOC__
+</StructureSection>
-==About this Structure==
-JA4 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JA4 OCA].
-==Reference==
-<ref group="xtra">PMID:17322294</ref><references group="xtra"/>
 [[Category: Homo sapiens]]
-[[Category: Blanco, F J.]]
+[[Category: Large Structures]]
-[[Category: Lozano, F.]]
+[[Category: Blanco FJ]]
-[[Category: Montoya, G.]]
+[[Category: Lozano F]]
-[[Category: Munoz, I G.]]
+[[Category: Montoya G]]
-[[Category: Rodamilans, B.]]
+[[Category: Munoz IG]]
-[[Category: Sarrias, M R.]]
+[[Category: Rodamilans B]]
-[[Category: Cd5]]
+[[Category: Sarrias MR]]
-[[Category: Cd6]]
-[[Category: Crystallography]]
-[[Category: Glycoprotein]]
-[[Category: Immune system]]
-[[Category: Innate immunity]]
-[[Category: Membrane]]
-[[Category: Phosphorylation]]
-[[Category: Polymorphism]]
-[[Category: Srcr]]
-[[Category: Transmembrane]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 22 11:16:09 2009''