2gtf: Difference between revisions

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-[[Image:2gtf.png|left|200px]]
-{{STRUCTURE_2gtf|  PDB=2gtf  |  SCENE=  }}
+==Crystal structure of nitrophorin 2 complex with pyrimidine==
+<StructureSection load='2gtf' size='340' side='right'caption='[[2gtf]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2gtf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rhodnius_prolixus Rhodnius prolixus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GTF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GTF FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=P1R:PYRIMIDINE'>P1R</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gtf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gtf OCA], [https://pdbe.org/2gtf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gtf RCSB], [https://www.ebi.ac.uk/pdbsum/2gtf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gtf ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/NP2_RHOPR NP2_RHOPR] Heme-based protein that deliver nitric oxide gas (NO) to the victim while feeding, resulting in vasodilation and inhibition of platelet aggregation. Also bind tightly to histamine, which is released by the host to induce wound healing (By similarity).  Specifically inhibits factor IXa-catalyzed activation of factor X in the presence of calcium and phospholipids irrespective of the presence or absence of factor VIIIa.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gt/2gtf_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2gtf ConSurf].
+<div style="clear:both"></div>
-===Crystal structure of nitrophorin 2 complex with pyrimidine===
+==See Also==
+*[[Nitrophorin|Nitrophorin]]
-{{ABSTRACT_PUBMED_10884386}}
+__TOC__
+</StructureSection>
-==About this Structure==
+[[Category: Large Structures]]
-[[2gtf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rhodnius_prolixus Rhodnius prolixus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GTF OCA].
-==Reference==
-<ref group="xtra">PMID:010884386</ref><references group="xtra"/>
 [[Category: Rhodnius prolixus]]
-[[Category: Montfort, W R.]]
+[[Category: Montfort WR]]
-[[Category: Weichsel, A.]]
+[[Category: Weichsel A]]
-[[Category: Beta barrel]]
-[[Category: Ferric heme]]
-[[Category: Lipocalin]]
-[[Category: Pyrimidine]]
-[[Category: Transport protein]]