2ehg: Difference between revisions

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-[[Image:2ehg.jpg|left|200px]]
- {{Structure
+==Crystal structure of hyperthermophilic archaeal RNase HI==
-|PDB= 2ehg |SIZE=350|CAPTION= <scene name='initialview01'>2ehg</scene>, resolution 1.60&Aring;
+<StructureSection load='2ehg' size='340' side='right'caption='[[2ehg]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
-|SITE=
+== Structural highlights ==
-|LIGAND=
+<table><tr><td colspan='2'>[[2ehg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sulfurisphaera_tokodaii_str._7 Sulfurisphaera tokodaii str. 7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EHG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EHG FirstGlance]. <br>
-|ACTIVITY= [http://en.wikipedia.org/wiki/Ribonuclease_H Ribonuclease H], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.26.4 3.1.26.4]
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
-|GENE=
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ehg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ehg OCA], [https://pdbe.org/2ehg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ehg RCSB], [https://www.ebi.ac.uk/pdbsum/2ehg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ehg ProSAT]</span></td></tr>
-}}
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/RNH_SULTO RNH_SULTO] Nuclease that specifically degrades the RNA of RNA-DNA hybrids. Endonucleolytically removes RNA primers from the Okazaki fragments of lagging strand synthesis on its own. In the presence of Mn(2+) or Co(2+) can also cleave an RNA-RNA hybrid; the dsRNase activity is 10- 100-fold lower than RNase H activity. Complements the temperature-sensitive phenotype of an E.coli double rnhA/rnhB (RNase H) disruption mutant.<ref>PMID:15520465</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/eh/2ehg_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ehg ConSurf].
+<div style="clear:both"></div>
-'''Crystal structure of hyperthermophilic archaeal RNase HI'''
+==See Also==
+*[[Ribonuclease 3D structures|Ribonuclease 3D structures]]
+== References ==
-==About this Structure==
+<references/>
-EHG is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Sulfolobus_tokodaii Sulfolobus tokodaii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EHG OCA].
+__TOC__
-[[Category: Ribonuclease H]]
+</StructureSection>
-[[Category: Single protein]]
+[[Category: Large Structures]]
-[[Category: Sulfolobus tokodaii]]
+[[Category: Sulfurisphaera tokodaii str. 7]]
-[[Category: Chon, H.]]
+[[Category: Chon H]]
-[[Category: Kanaya, S.]]
+[[Category: Kanaya S]]
-[[Category: Koga, Y.]]
+[[Category: Koga Y]]
-[[Category: Takano, K.]]
+[[Category: Takano K]]
-[[Category: You, D J.]]
+[[Category: You DJ]]
-[[Category: double-stranded rna-dependent rnase]]
-[[Category: hydrolase]]
-[[Category: hyperthermophilic archaeon]]
-[[Category: rnase hi]]
-[[Category: sulfolobus tokodaii]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:40:11 2008''