2e9e: Difference between revisions

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{{STRUCTURE_2e9e|  PDB=2e9e  |  SCENE=  }}
==Crystal structure of the complex of goat lactoperoxidase with Nitrate at 3.25 A resolution==
 
<StructureSection load='2e9e' size='340' side='right'caption='[[2e9e]], [[Resolution|resolution]] 3.25&Aring;' scene=''>
===Crystal structure of the complex of goat lactoperoxidase with Nitrate at 3.25 A resolution===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[2e9e]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Capra_hircus Capra hircus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E9E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2E9E FirstGlance]. <br>
 
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.25&#8491;</td></tr>
==About this Structure==
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=CYN:CYANIDE+ION'>CYN</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene>, <scene name='pdbligand=OSM:1-(OXIDOSULFANYL)METHANAMINE'>OSM</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene></td></tr>
[[2e9e]] is a 2 chain structure of [[Lactoperoxidase]] with sequence from [http://en.wikipedia.org/wiki/Capra_hircus Capra hircus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E9E OCA].  
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2e9e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e9e OCA], [https://pdbe.org/2e9e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2e9e RCSB], [https://www.ebi.ac.uk/pdbsum/2e9e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2e9e ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PERL_CAPHI PERL_CAPHI] Antimicrobial agent which utilizes hydrogen peroxide and thiocyanate (SCN) to generate the antimicrobial substance hypothiocyanous acid (HOSCN) (PubMed:10894086). May protect the udder from infection and promote growth in newborns. Inhibits growth of several fungi including A.niger, Trichoderma species, C.cassicola, P.meadii and C.salmonicolor (PubMed:10894086). Does not have anti-fungal activity towards C.albicans and Pythium species (PubMed:10894086). Inhibits growth of several Gram-positive bacteria including some Staphylococcus species and Gram-negative bacteria including E.coli, P.aeruginosa and some Salmonella species (PubMed:10894086).<ref>PMID:10894086</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e9/2e9e_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2e9e ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Lactoperoxidase|Lactoperoxidase]]
*[[Lactoperoxidase|Lactoperoxidase]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Capra hircus]]
[[Category: Capra hircus]]
[[Category: Peroxidase]]
[[Category: Large Structures]]
[[Category: Bhushan, A.]]
[[Category: Bhushan A]]
[[Category: Kaur, P.]]
[[Category: Kaur P]]
[[Category: Sharma, S.]]
[[Category: Prem kumar R]]
[[Category: Singh, A K.]]
[[Category: Sharma S]]
[[Category: Singh, N.]]
[[Category: Singh AK]]
[[Category: Singh, S B.]]
[[Category: Singh N]]
[[Category: Singh, T P.]]
[[Category: Singh SB]]
[[Category: Kumar, R Prem.]]
[[Category: Singh TP]]
[[Category: Complex]]
[[Category: Lactoperoxidase]]
[[Category: Metal binding protein]]
[[Category: Milk protein]]
[[Category: Nitrate]]
[[Category: Oxidoreductase]]

Latest revision as of 08:11, 17 October 2024

Crystal structure of the complex of goat lactoperoxidase with Nitrate at 3.25 A resolutionCrystal structure of the complex of goat lactoperoxidase with Nitrate at 3.25 A resolution

Structural highlights

2e9e is a 2 chain structure with sequence from Capra hircus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 3.25Å
Ligands:, , , , , , , , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

PERL_CAPHI Antimicrobial agent which utilizes hydrogen peroxide and thiocyanate (SCN) to generate the antimicrobial substance hypothiocyanous acid (HOSCN) (PubMed:10894086). May protect the udder from infection and promote growth in newborns. Inhibits growth of several fungi including A.niger, Trichoderma species, C.cassicola, P.meadii and C.salmonicolor (PubMed:10894086). Does not have anti-fungal activity towards C.albicans and Pythium species (PubMed:10894086). Inhibits growth of several Gram-positive bacteria including some Staphylococcus species and Gram-negative bacteria including E.coli, P.aeruginosa and some Salmonella species (PubMed:10894086).[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Benoy MJ, Essy AK, Sreekumar B, Haridas M. Thiocyanate mediated antifungal and antibacterial property of goat milk lactoperoxidase. Life Sci. 2000;66(25):2433-9. doi: 10.1016/s0024-3205(00)80003-x. PMID:10894086 doi:http://dx.doi.org/10.1016/s0024-3205(00)80003-x

2e9e, resolution 3.25Å

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