2dx0: Difference between revisions
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<StructureSection load='2dx0' size='340' side='right'caption='[[2dx0]], [[Resolution|resolution]] 2.50Å' scene=''> | <StructureSection load='2dx0' size='340' side='right'caption='[[2dx0]], [[Resolution|resolution]] 2.50Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2dx0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2dx0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DX0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DX0 FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dx0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dx0 OCA], [https://pdbe.org/2dx0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dx0 RCSB], [https://www.ebi.ac.uk/pdbsum/2dx0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dx0 ProSAT], [https://www.topsan.org/Proteins/RSGI/2dx0 TOPSAN]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dx0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dx0 OCA], [https://pdbe.org/2dx0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dx0 RCSB], [https://www.ebi.ac.uk/pdbsum/2dx0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dx0 ProSAT], [https://www.topsan.org/Proteins/RSGI/2dx0 TOPSAN]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/PLCG2_MOUSE PLCG2_MOUSE] The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling (By similarity). | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dx/2dx0_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dx/2dx0_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/ | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: | [[Category: Mus musculus]] | ||
[[Category: Handa | [[Category: Handa N]] | ||
[[Category: Murayama | [[Category: Murayama K]] | ||
[[Category: Shirouzu M]] | |||
[[Category: Shirouzu | [[Category: Takagi T]] | ||
[[Category: Takagi | [[Category: Terada T]] | ||
[[Category: Terada | [[Category: Yokoyama S]] | ||
[[Category: Yokoyama | |||
Latest revision as of 08:10, 17 October 2024
Crystal structure of the N-terminal SH2 domain of mouse phospholipase C-gamma 2Crystal structure of the N-terminal SH2 domain of mouse phospholipase C-gamma 2
Structural highlights
FunctionPLCG2_MOUSE The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling (By similarity). Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. See Also |
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