2dx0: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-[[Image:2dx0.jpg|left|200px]]
- {{Structure
+==Crystal structure of the N-terminal SH2 domain of mouse phospholipase C-gamma 2==
-|PDB= 2dx0 |SIZE=350|CAPTION= <scene name='initialview01'>2dx0</scene>, resolution 2.50&Aring;
+<StructureSection load='2dx0' size='340' side='right'caption='[[2dx0]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
-|SITE=
+== Structural highlights ==
-|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
+<table><tr><td colspan='2'>[[2dx0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DX0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DX0 FirstGlance]. <br>
-|ACTIVITY=
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
-|GENE=
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-|DOMAIN=
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dx0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dx0 OCA], [https://pdbe.org/2dx0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dx0 RCSB], [https://www.ebi.ac.uk/pdbsum/2dx0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dx0 ProSAT], [https://www.topsan.org/Proteins/RSGI/2dx0 TOPSAN]</span></td></tr>
-|RELATEDENTRY=
+</table>
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dx0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dx0 OCA], [http://www.ebi.ac.uk/pdbsum/2dx0 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2dx0 RCSB]</span>
+== Function ==
-}}
+[https://www.uniprot.org/uniprot/PLCG2_MOUSE PLCG2_MOUSE] The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling (By similarity).
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dx/2dx0_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2dx0 ConSurf].
+<div style="clear:both"></div>
-'''Crystal structure of the N-terminal SH2 domain of mouse phospholipase C-gamma 2'''
+==See Also==
+*[[Phospholipase C|Phospholipase C]]
+__TOC__
-==About this Structure==
+</StructureSection>
-DX0 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DX0 OCA].
+[[Category: Large Structures]]
 [[Category: Mus musculus]]
-[[Category: Single protein]]
+[[Category: Handa N]]
-[[Category: Handa, N.]]
+[[Category: Murayama K]]
-[[Category: Murayama, K.]]
+[[Category: Shirouzu M]]
-[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
+[[Category: Takagi T]]
-[[Category: Shirouzu, M.]]
+[[Category: Terada T]]
-[[Category: Takagi, T.]]
+[[Category: Yokoyama S]]
-[[Category: Terada, T.]]
-[[Category: Yokoyama, S.]]
-[[Category: national project on protein structural and functional analyse]]
-[[Category: nppsfa]]
-[[Category: phosphoric diester hydrolase]]
-[[Category: riken structural genomics/proteomics initiative]]
-[[Category: rsgi]]
-[[Category: structural genomic]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:40:44 2008''