2bo2: Difference between revisions

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OCA

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 ==EGF Domains 1,2,5 of human EMR2, a 7-TM immune system molecule, in complex with calcium.==
-<StructureSection load='2bo2' size='340' side='right' caption='[[2bo2]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
+<StructureSection load='2bo2' size='340' side='right'caption='[[2bo2]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2bo2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BO2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BO2 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2bo2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BO2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BO2 FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2bou|2bou]], [[2box|2box]]</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bo2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bo2 OCA], [http://pdbe.org/2bo2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2bo2 RCSB], [http://www.ebi.ac.uk/pdbsum/2bo2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2bo2 ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bo2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bo2 OCA], [https://pdbe.org/2bo2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bo2 RCSB], [https://www.ebi.ac.uk/pdbsum/2bo2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bo2 ProSAT]</span></td></tr>
 </table>
+== Disease ==
+[https://www.uniprot.org/uniprot/AGRE2_HUMAN AGRE2_HUMAN] Vibratory urticaria. The disease is caused by variants affecting the gene represented in this entry.
 == Function ==
-[[http://www.uniprot.org/uniprot/EMR2_HUMAN EMR2_HUMAN]] Cell surface receptor that binds to the chondroitin sulfate moiety of glycosaminoglycan chains and promotes cell attachment. Promotes granulocyte chemotaxis, degranulation and adhesion. In macrophages, promotes the release of inflammatory cytokines, including IL8 and TNF.<ref>PMID:12829604</ref> <ref>PMID:17928360</ref> <ref>PMID:22310662</ref>
+[https://www.uniprot.org/uniprot/AGRE2_HUMAN AGRE2_HUMAN] Cell surface receptor that binds to the chondroitin sulfate moiety of glycosaminoglycan chains and promotes cell attachment. Promotes granulocyte chemotaxis, degranulation and adhesion. In macrophages, promotes the release of inflammatory cytokines, including IL8 and TNF. Signals probably through G-proteins. Is a regulator of mast cell degranulation (PubMed:26841242).<ref>PMID:12829604</ref> <ref>PMID:17928360</ref> <ref>PMID:22310662</ref> <ref>PMID:22575658</ref> <ref>PMID:26841242</ref>
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 15: / Line 17: @@
    <jmolCheckbox>
      <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bo/2bo2_consurf.spt"</scriptWhenChecked>
-     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
      <text>to colour the structure by Evolutionary Conservation</text>
    </jmolCheckbox>
@@ Line 33: / Line 35: @@
 __TOC__
 </StructureSection>
-[[Category: Human]]
+[[Category: Homo sapiens]]
-[[Category: Abbott, R J.M]]
+[[Category: Large Structures]]
-[[Category: Handford, P A]]
+[[Category: Abbott RJM]]
-[[Category: Knott, V]]
+[[Category: Handford PA]]
-[[Category: Lea, S M]]
+[[Category: Knott V]]
-[[Category: McDonnell, J M]]
+[[Category: Lea SM]]
-[[Category: Roversi, P]]
+[[Category: McDonnell JM]]
-[[Category: Spendlove, I]]
+[[Category: Roversi P]]
-[[Category: Teriete, P]]
+[[Category: Spendlove I]]
-[[Category: Calcium-binding]]
+[[Category: Teriete P]]
-[[Category: Cd55]]
-[[Category: Cd97]]
-[[Category: Cell adhesion]]
-[[Category: Egf-like domain]]
-[[Category: G-protein coupled receptor]]
-[[Category: Immune system]]