1z3q: Difference between revisions

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-{{Seed}}
-[[Image:1z3q.png|left|200px]]
-<!--
+==Resolution of the structure of the allergenic and antifungal banana fruit thaumatin-like protein at 1.7A==
-The line below this paragraph, containing "STRUCTURE_1z3q", creates the "Structure Box" on the page.
+<StructureSection load='1z3q' size='340' side='right'caption='[[1z3q]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1z3q]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Musa_acuminata Musa acuminata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z3Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z3Q FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
-{{STRUCTURE_1z3q|  PDB=1z3q  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z3q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z3q OCA], [https://pdbe.org/1z3q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z3q RCSB], [https://www.ebi.ac.uk/pdbsum/1z3q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z3q ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/O22322_MUSAC O22322_MUSAC]
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z3/1z3q_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1z3q ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+The structure of a thaumatin-like protein from banana (Musa acuminata) fruit, an allergen with antifungal properties, was solved at 1.7-A-resolution, by X-ray crystallography. Though the banana protein exhibits a very similar overall fold as thaumatin it markedly differs from the sweet-tasting protein by the presence of a surface exposed electronegative cleft. Due to the presence of this electronegative cleft, the banana thaumatin-like protein (Ban-TLP) acquires a strong (local) electronegative character that eventually explains the observed antifungal activity. Our structural analysis also revealed the presence of conserved residues of exposed epitopic determinants that are presumably responsible for the allergenic properties of banana fruit towards susceptible individuals, and provided evidence that the Ban-TLP shares some structurally highly conserved IgE-binding epitopes with thaumatin-like proteins from fruits or pollen from other plants. In addition, some overlap was detected between the predicted IgE-binding epitopes of the Ban-TLP and IgE-binding epitopes previously identified in the mountain cedar Jun a 3 TLP aeroallergen. The presence of these common epitopes offers a molecular basis for the cross-reactivity between aeroallergens and fruit allergens.
-===Resolution of the structure of the allergenic and antifungal banana fruit thaumatin-like protein at 1.7A===
+Resolution of the structure of the allergenic and antifungal banana fruit thaumatin-like protein at 1.7-A.,Leone P, Menu-Bouaouiche L, Peumans WJ, Payan F, Barre A, Roussel A, Van Damme EJ, Rouge P Biochimie. 2006 Jan;88(1):45-52. Epub 2005 Aug 8. PMID:16085352<ref>PMID:16085352</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-<!--
+</div>
-The line below this paragraph, {{ABSTRACT_PUBMED_16085352}}, adds the Publication Abstract to the page
+<div class="pdbe-citations 1z3q" style="background-color:#fffaf0;"></div>
-(as it appears on PubMed at http://www.pubmed.gov), where 16085352 is the PubMed ID number.
+== References ==
--->
+<references/>
-{{ABSTRACT_PUBMED_16085352}}
+__TOC__
+</StructureSection>
-==About this Structure==
+[[Category: Large Structures]]
-Z3Q is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Musa_acuminata Musa acuminata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z3Q OCA].
-==Reference==
-<ref group="xtra">PMID:16085352</ref><references group="xtra"/>
 [[Category: Musa acuminata]]
-[[Category: Barre, A.]]
+[[Category: Barre A]]
-[[Category: Damme, E J.M Van.]]
+[[Category: Leone P]]
-[[Category: Leone, P.]]
+[[Category: Menu-Bouaouiche L]]
-[[Category: Menu-Bouaouiche, L.]]
+[[Category: Payan F]]
-[[Category: Payan, F.]]
+[[Category: Peumans WJ]]
-[[Category: Peumans, W J.]]
+[[Category: Rouge P]]
-[[Category: Rouge, P.]]
+[[Category: Roussel A]]
-[[Category: Roussel, A.]]
+[[Category: Van Damme EJM]]
-[[Category: Beta sandwich]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 03:50:04 2009''